4-(6-iodo-2,3-dimethoxyphenylamino)-but-2-enoic acid methyl ester

Base Information

• Chemical Name: 4-(6-iodo-2,3-dimethoxyphenylamino)-but-2-enoic acid methyl ester
• CAS No.: 1020105-52-5
• Molecular Formula: C₁₃H₁₆INO₄
• Molecular Weight: 377.179
• Mol file: 1020105-52-5.mol

Synonyms:4-(6-iodo-2,3-dimethoxyphenylamino)-but-2-enoic acid methyl ester

Chemical Property of 4-(6-iodo-2,3-dimethoxyphenylamino)-but-2-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-(6-iodo-2,3-dimethoxyphenylamino)-but-2-enoic acid methyl ester

There total 2 articles about 4-(6-iodo-2,3-dimethoxyphenylamino)-but-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

6-iodo-2,3-dimethoxyphenylamine (908003-67-8) + methyl-4-bromo-2-butenoate (1117-71-1,56699-18-4,6000-00-6) → 4-(6-iodo-2,3-dimethoxyphenylamino)-but-2-enoic acid methyl ester (1020105-52-5)

Guidance literature:

With sodium hydrogencarbonate; In water; acetone; for 3h; Heating;

DOI:10.1021/ol061137i

Reference yield:

2,3-dimethoxyaniline (6299-67-8) → 4-(6-iodo-2,3-dimethoxyphenylamino)-but-2-enoic acid methyl ester (1020105-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / iodine monochloride; Na₂CO₃ / diethyl ether; H₂O / 2 h

2: 47 percent / NaHCO₃ / acetone; H₂O / 3 h / Heating

With Iodine monochloride; sodium hydrogencarbonate; sodium carbonate; In diethyl ether; water; acetone;

DOI:10.1021/ol061137i

Reference yield: 90.0%

4-(6-iodo-2,3-dimethoxyphenylamino)-but-2-enoic acid methyl ester (1020105-52-5) → (6,7-dimethoxy-1H-indol-3-yl)-acetic acid methyl ester (908003-80-5)

Guidance literature:

With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile; for 3h; Heating;

DOI:10.1021/ol061137i

upstream raw materials:

6-iodo-2,3-dimethoxyphenylamine

methyl-4-bromo-2-butenoate

2,3-dimethoxyaniline

Downstream raw materials:

(6,7-dimethoxy-1H-indol-3-yl)-acetic acid methyl ester