methyl {[(4-methylphenyl)sulfonyl]oxy}acetate

Base Information

• Chemical Name: methyl {[(4-methylphenyl)sulfonyl]oxy}acetate
• CAS No.: 88016-30-2
• Molecular Formula: C10H12 O5 S
• Molecular Weight: 244.268
• Mol file: 88016-30-2.mol

Synonyms:Aceticacid, [[(4-methylphenyl)sulfonyl]oxy]-, methyl ester (9CI);(Methoxycarbonyl)methyl p-tosylate; Methyl tosyloxyacetate; NSC 211686

Chemical Property of methyl {[(4-methylphenyl)sulfonyl]oxy}acetate

Chemical Property:

• Vapor Pressure: 1.55E-05mmHg at 25°C
• Boiling Point: 365.7°Cat760mmHg
• Flash Point: 174.9°C
• Density: 1.283g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl {[(4-methylphenyl)sulfonyl]oxy}acetate

There total 5 articles about methyl {[(4-methylphenyl)sulfonyl]oxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

glycolic acid methyl ester (96-35-5) + p-toluenesulfonyl chloride (98-59-9) → (methoxycarbonyl)methyl p-toluenesulfonate (88016-30-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 - 25 ℃; for 1h; Inert atmosphere;

DOI:10.1002/adsc.201700879

Reference yield: 66.0%

methanol (67-56-1) + [hydroxy(tosyloxy)iodo]benzene (27126-76-7) + acetic anhydride (108-24-7) → iodobenzene (591-50-4) + acetic acid methyl ester (79-20-9) + (methoxycarbonyl)methyl p-toluenesulfonate (88016-30-2)

Guidance literature:

[hydroxy(tosyloxy)iodo]benzene; acetic anhydride; at 100 ℃; for 0.333333h;

methanol; With toluene-4-sulfonic acid; for 4h; Heating;

DOI:10.1016/S0040-4039(01)01028-0

Reference yield: 40.0%

methyl 2-iodoacetate (5199-50-8) + [hydroxy(tosyloxy)iodo]benzene (27126-76-7) → (methoxycarbonyl)methyl p-toluenesulfonate (88016-30-2)

Guidance literature:

In chloroform; at 25 ℃; for 120h; further solvent;

DOI:10.1007/BF00954382

upstream raw materials:

methyl 2-iodoacetate

[hydroxy(tosyloxy)iodo]benzene

methanol

acetic anhydride

Downstream raw materials:

4-phenyl-1-(2-methoxyethan-2-on-1-yl)-1H-1,2,3-triazole

(methoxycarbonylmethyl)tetracarbonyltriphenylphosphinemanganese

C₁₈H₁₇N₃O₂

C₁₈H₁₇N₃O₂