(3R,4S)-1-Benzoyl-3-acetoxy-4-phenyl-2-azetidinone

Base Information

• Chemical Name: (3R,4S)-1-Benzoyl-3-acetoxy-4-phenyl-2-azetidinone
• CAS No.: 146924-93-8
• Molecular Formula: C₁₈H₁₅NO₄
• Molecular Weight: 309.321
• Mol file: 146924-93-8.mol

Synonyms:(3R,4S)-1-Benzoyl-2-oxo-4-phenylazetidin-3-yl acetate;(3R,4S)-1-benzoyl-3-acetoxy-4-phenyl-2-azetidinone;

Chemical Property of (3R,4S)-1-Benzoyl-3-acetoxy-4-phenyl-2-azetidinone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.627
• Boiling Point: 455.28 °C at 760 mmHg
• Flash Point: 229.145 °C
• PSA: 63.68000
• Density: 1.319 g/cm³
• LogP: 2.27990

Purity/Quality:

99% ^*data from raw suppliers

(3R-cis)-3-(Acetyloxy)-1-benzoyl-4-phenyl-2-azetidinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3R,4S)-1-Benzoyl-3-acetoxy-4-phenyl-2-azetidinone

There total 1 articles about (3R,4S)-1-Benzoyl-3-acetoxy-4-phenyl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(+/-)-cis-1-benzoyl-3-acetoxy-4-phenylazetidin-2-one (146924-93-8) → (3S,4R)-1-Benzoyl-3-hydroxy-4-phenyl-azetidin-2-one + (+)-cis-1-benzoyl-3-acetoxy-4-phenylazetidin-2-one (146924-93-8)

Guidance literature:

With water; In various solvent(s); at 50 ℃; for 48h; Pseudomonas cepacia lipase P-30 on Celite;

DOI:10.1021/jo00057a018

Reference yield: 42.0%

methanol (67-56-1) + (+/-)-cis-1-benzoyl-3-acetoxy-4-phenylazetidin-2-one (146924-93-8) → (3S,4R)-1-Benzoyl-3-hydroxy-4-phenyl-azetidin-2-one + methyl (2R,3S)-2-acetoxy-3-phenyl-3-benzoylaminopropanoate (146848-86-4)

Guidance literature:

In various solvent(s); at 50 ℃; for 48h; Pseudomonas sp. lipase AK;

DOI:10.1021/jo00057a018

Downstream raw materials:

methyl (2R,3S)-2-acetoxy-3-phenyl-3-benzoylaminopropanoate

Refernces