146848-86-4

Upstream product

• 18107-18-1 diazomethyl-trimethyl-silane 
• 745076-37-3 (2R,3S)-N-benzoyl-O-acetyl-3-phenylisoserine 
• 55-21-0 benzamide 
• 622851-09-6 (1S,2S)-[2-phenyl-2-benzylamino-1-(3-furyl)-ethyl]acetate 
• 622851-12-1 (1S,2S)-N-[1-phenyl-2-hydroxy-2-(3-furyl)-ethyl]benzamide 
• 622851-14-3 (2S,3S)-2-(3-furyl)-3-phenyl-1-benzoylaziridine 
• 622851-08-5 (4S,5S)-1,4-diphenyl-5-(3-furyl)-4,5-dihydro-oxazole 
• 622851-11-0 (2S,3S)-2-(3-furyl)-3-phenylaziridine 
• 100-52-7 benzaldehyde 
• 117067-48-8 1-benzotriazolyl-N-benzoyl-1-phenylmethylamine 
• 10387-93-6 N-(methoxy(phenyl)methyl)benzamide 
• 67-56-1 methanol 
• 146924-93-8 (+/-)-cis-1-benzoyl-3-acetoxy-4-phenylazetidin-2-one 
• 98-88-4 benzoyl chloride 

Downstream Products

• 32981-85-4 methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 
• 132201-33-3 (2R,3S)-N-benzoyl-3-phenylisoserine 

Relevant academic research and scientific papers

Asymmetric Sulfur Ylide Mediated Aziridination: Application in the Synthesis of the Side Chain of Taxol

(Formula presented). Sulfur ylide methodology has been used to construct the Taxol side chain with a high degree of enantioselectivity via a trans-aziridine followed by stereospecific rearrangement of the trans-benzoylaziridine into a trans-oxazoline.

Chemoenzymatic Synthesis of the C-13 Side Chain of Taxol: Optically Active 3-Hydroxy-4-phenyl β-Lactam Derivatives

Enantiomerically pure 3-hydroxy-4-phenyl β-lactam derivatives have been successfully prepared via enantioselective hydrolyses and transesterifications of racemic esters and alcohols respectivily catalyzed by bacterial lipases.These lipases also catalyzed highly enantioselective cleavage of the β-lactam ring of (+/-)-10 to yield derivatives of (2R,3S)-phenylisoserine in high enantiomeric excess.The resolved enantiomers are important intermediates in the synthesis of the C-13 side chain of taxol.