Benzyl hydroxy(4-phenylbutyl)phosphinoylacetate

Base Information

• Chemical Name: Benzyl hydroxy(4-phenylbutyl)phosphinoylacetate
• CAS No.: 87460-09-1
• Molecular Formula: C19H23O4P
• Molecular Weight: 346.363
• Hs Code.: 2918990090
• Mol file: 87460-09-1.mol

Synonyms:Aceticacid, [hydroxy(4-phenylbutyl)phosphinyl]-, phenylmethyl ester (9CI);Acetic acid, 2-[hydroxy(4-phenylbutyl)phosphinyl]-, phenylmethyl ester;[2-(Benzyloxy)-2-oxoethyl](4-phenylbutyl)phosphinic acid;acetic acid, 2-[hydroxy(4-phenylbutyl)phosphinyl]-, phenylmethyl ester;Phenylmethyl 2-[hydroxy(4-phenylbutyl)phosphinyl]acetate;Benzyl hydroxy(4-phenylbutyl)phosphinoylacetate;

Chemical Property of Benzyl hydroxy(4-phenylbutyl)phosphinoylacetate

Chemical Property:

• Vapor Pressure: 2.28E-14mmHg at 25°C
• Melting Point: 65-67ºC
• Refractive Index: 1.557
• Boiling Point: 581.6 °C at 760 mmHg
• PKA: 2.52±0.50(Predicted)
• Flash Point: 305.5 °C
• PSA: 73.41000
• Density: 1.191 g/cm³
• LogP: 4.02310
• Storage Temp.: -20?C Freezer
• Solubility.: Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

BenzylHydroxy(4-phenylbutyl)phosphinoacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-36/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the synthesis of angiotensin and fosinopril. Impurity in the preparation of Fosinopril Sodium.

Technology Process of Benzyl hydroxy(4-phenylbutyl)phosphinoylacetate

There total 8 articles about Benzyl hydroxy(4-phenylbutyl)phosphinoylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

diethyl ether (60-29-7,927820-24-4) + (4-phenylbutyl)phosphinic acid (86552-32-1) + Benzyl bromoacetate (5437-45-6) → [Hydroxy-(4-phenylbutyl)phosphinyl]acetic acid,phenylmethyl ester (87460-09-1)

Guidance literature:

With hydrogenchloride; chloro-trimethyl-silane; triethylamine; In hexane; chloroform; water;

Reference yield:

(hydroxy(4-phenylbutyl)-phosphinyl)acetic acid (83623-61-4) + benzyl chloroformate (501-53-1,94274-21-2) → [Hydroxy-(4-phenylbutyl)phosphinyl]acetic acid,phenylmethyl ester (87460-09-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; sodium hydrogencarbonate;

Reference yield:

chloro-trimethyl-silane (75-77-4) + 4-Phenylbutylphosphonous acid (344407-83-6) + Benzyl bromoacetate (5437-45-6) → [Hydroxy-(4-phenylbutyl)phosphinyl]acetic acid,phenylmethyl ester (87460-09-1)

Guidance literature:

With triethylamine; In hexane; chloroform;

upstream raw materials:

(4-phenylbutyl)phosphinic acid

C₁₆H₃₁O₂PSi₂

diethyl ether

Benzyl bromoacetate

Downstream raw materials:

[[2-Methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)phosphinyl]acetic acid

Refernces

• 1、 -. "Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby". . . Retrieved 2008/06/13.
• 2、 Thottathil, John K.,Przybyla, Claire A.,Moniot, Jerome L.. "MILD ARBUZOV REACTIONS OF PHOSPHONOUS ACIDS". . p. 4737 - 4740. Retrieved 2007/10/02.