2H-Bezofuran-3-one

Base Information

• Chemical Name: 2H-Bezofuran-3-one
• CAS No.: 71699-34-8
• Molecular Formula: C9H18 O2
• Molecular Weight: 134.13
• Hs Code.: 2914400090
• Mol file: 71699-34-8.mol

Synonyms:3-Heptanone,5-hydroxy-4,6-dimethyl-, (R*,R*)-

Chemical Property of 2H-Bezofuran-3-one

Chemical Property:

• Boiling Point: 232.5±13.0 °C(Predicted)
• PKA: 14.32±0.20(Predicted)
• PSA: 26.30000
• Density: 0.915±0.06 g/cm3(Predicted)
• LogP: 1.26170

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Bezofuran-3-one

There total 12 articles about 2H-Bezofuran-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(5S,6S)-4-Eth-(Z)-ylidene-6-isopropyl-5-methyl-[1,3]dioxan-2-one → 5-hydroxy-4,6-dimethylheptan-3-one (71699-34-8)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo990439d

Reference yield: 72.0%

isobutyraldehyde (78-84-2) + pentan-3-one (96-22-0) → 5-hydroxy-4,6-dimethylheptan-3-one (71699-34-8)

Guidance literature:

With titanium(IV) isopropylate; phenylmagnesium bromide; In toluene; for 6h; Ambient temperature;

DOI:10.1016/0040-4020(95)00496-U

Reference yield:

isobutyraldehyde (78-84-2) + pentan-3-one (96-22-0) → 5-hydroxy-4,6-dimethylheptan-3-one (71699-34-8) + 5-hydroxy-4,6-dimethyl-3-heptanone (71699-33-7)

Guidance literature:

With 1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; In dichloromethane; at -78 ℃; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)82423-6

upstream raw materials:

2-bromopentan-3-one

isobutyraldehyde

Cyclohexyl-((E)-1-ethyl-propenyl)-trimethylsilanyl-amine

pentan-3-one

Downstream raw materials:

3,4-anti-3-<(benzyloxy)methoxy>-2,4-dimethyl-5-heptanone

Refernces

• 1、 Godenschwager, Peter F.,Collum, David B.. "Lithium hexamethyldisilazide-mediated enolizations: Influence of triethylamine on E/Z selectivities and enolate reactivities". supporting information; experimental part. p. 8726 - 8732. Retrieved 2009/02/02.
• 2、 Mukaiyama, Teruaki,Imachi, Shouhei,Yamane, Keiko,Mizuta, Masahiro. "Stereoselective crossed aldol reaction via boron enolate generated from α-iodoketones and 9-BBN-H". . p. 698 - 699. Retrieved 2007/10/03.