5-hydroxy-4,6-dimethyl-3-heptanone

Base Information

• Chemical Name: 5-hydroxy-4,6-dimethyl-3-heptanone
• CAS No.: 71699-33-7
• Molecular Formula: C₉H₁₈O₂
• Molecular Weight: 158.241
• Mol file: 71699-33-7.mol

Synonyms:5-hydroxy-4,6-dimethyl-3-heptanone

Chemical Property of 5-hydroxy-4,6-dimethyl-3-heptanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-4,6-dimethyl-3-heptanone

There total 8 articles about 5-hydroxy-4,6-dimethyl-3-heptanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isobutyraldehyde (78-84-2) + pentan-3-one (96-22-0) → 5-hydroxy-4,6-dimethylheptan-3-one (71699-34-8) + 5-hydroxy-4,6-dimethyl-3-heptanone (71699-33-7)

Guidance literature:

With 1-ethyl-piperidine; tin(II) trifluoromethanesulfonate; In dichloromethane; at -78 ℃; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4020(01)82423-6

Reference yield:

2-bromopentan-3-one (815-52-1) + isobutyraldehyde (78-84-2) → anti-5-hydroxy-4,6-dimethyl-3-heptanone (58547-33-4,71699-33-7,71699-34-8,108211-87-6,113626-45-2,129311-86-0,129388-00-7) + syn-5-hydroxy-4,6-dimethyl-3-heptanone

Guidance literature:

With tert-butyl isocyanide; titanium chloride; copper; In dichloromethane; at -23 ℃; for 3h; Title compound not separated from byproducts;

DOI:10.1246/bcsj.73.2579

Reference yield:

2-bromopentan-3-one (815-52-1) + isobutyraldehyde (78-84-2) → 5-hydroxy-4,6-dimethylheptan-3-one (71699-34-8) + 5-hydroxy-4,6-dimethyl-3-heptanone (71699-33-7)

Guidance literature:

With tin; In dichloromethane; N,N-dimethyl-formamide; at -78 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1246/cl.1982.467

upstream raw materials:

2-bromopentan-3-one

isobutyraldehyde

Cyclohexyl-((E)-1-ethyl-propenyl)-trimethylsilanyl-amine

pentan-3-one

Downstream raw materials:

(3S,4R,6R,7R)-3-Benzyloxymethoxy-7-hydroxy-2,4,6,8-tetramethyl-nonan-5-one

(3S,4R,6R,7S)-3-Benzyloxymethoxy-7-hydroxy-2,4,6,8-tetramethyl-nonan-5-one

(3S,4R,6S,7R)-3-Benzyloxymethoxy-7-hydroxy-2,4,6,8-tetramethyl-nonan-5-one

(3S,4R,6R,7S)-3-Benzyloxy-7-hydroxy-2,4,6,8-tetramethyl-nonan-5-one