444615-63-8

Upstream product

• 22179-72-2 4-fluorothiobenzamide 
• 34034-87-2 diethyl 3-chloro-2-oxosuccinate 
• 72505-21-6 4-trifluoromethylbenzthioamide 

Downstream Products

• 444615-64-9 {2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-4,5-diyl}dimethanol 
• 444613-82-5 2-(4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenoxy)-2-methylpropanoic acid ethyl ester 
• 676348-79-1 4-{[(4-{[4-(4-methoxyphenyl)piperazin-1-yl]methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl)methyl]sulfanyl}phenol 
• 444613-83-6 2-{4-[4-methanesulfonyloxymethyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-phenoxy}-2-methyl-propionic acid ethyl ester 
• 444613-51-8 ethyl 2-{4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}-2-methylpropanoate 
• 676348-78-0 4-[({4-(hydroxymethyl)-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenol 

Relevant academic research and scientific papers

An efficient synthesis of a potent PPARpan agonist

An efficient synthesis of 2-{4-[({4-{[4-(4-methoxyphenyl)-piperazin-1-yl] methyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)thio]phenoxy} -2-methylpropanoic acid (1), a potent PPARpan agonist, is described. The seven-step synthesis, which affo

Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors

The present invention provides a compound of formula (1) wherein R1-R5, R25, R26, Y and X2 are defined as in claim 1. The compounds activate human peroxisome proliferator activated receptors (hPPARs) and arc useful for the treatment of associated disorders such as cardiovascular disease and hypercholesteremia.