1-benzyl-2-((2-iodo-4-cyano-phenyl)methyl)pyridinium bromide

Base Information

• Chemical Name: 1-benzyl-2-((2-iodo-4-cyano-phenyl)methyl)pyridinium bromide
• CAS No.: 1423122-99-9
• Molecular Formula: Br*C₂₀H₁₆IN₂
• Molecular Weight: 491.169
• Mol file: 1423122-99-9.mol

Synonyms:1-benzyl-2-((2-iodo-4-cyano-phenyl)methyl)pyridinium bromide

Chemical Property of 1-benzyl-2-((2-iodo-4-cyano-phenyl)methyl)pyridinium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-2-((2-iodo-4-cyano-phenyl)methyl)pyridinium bromide

There total 6 articles about 1-benzyl-2-((2-iodo-4-cyano-phenyl)methyl)pyridinium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(phenylsulfonyl)pyridine (24244-60-8) + 3-iodo-4-methylbenzonitrile (42872-79-7) + benzyl bromide (100-39-0) → 1-benzyl-2-((2-iodo-4-cyano-phenyl)methyl)pyridinium bromide (1423122-99-9)

Guidance literature:

2-(phenylsulfonyl)pyridine; 3-iodo-4-methylbenzonitrile; With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 10 - 20 ℃; for 2h; Inert atmosphere; Large scale;

benzyl bromide; In acetonitrile; at 80 ℃; for 18h; Large scale;

Reference yield:

2-(phenylsulfonyl)pyridine (24244-60-8) → 1-benzyl-2-((2-iodo-4-cyano-phenyl)methyl)pyridinium bromide (1423122-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 20 - 25 °C / Inert atmosphere

2: tetrahydrofuran; acetonitrile / 12 h / 80 °C / Inert atmosphere

With sodium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jacs.6b09764

Reference yield:

3-iodo-4-methylbenzonitrile (42872-79-7) → 1-benzyl-2-((2-iodo-4-cyano-phenyl)methyl)pyridinium bromide (1423122-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / 20 - 25 °C / Inert atmosphere

2: tetrahydrofuran; acetonitrile / 12 h / 80 °C / Inert atmosphere

With sodium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jacs.6b09764

upstream raw materials:

2-(phenylsulfonyl)pyridine

3-iodo-4-methylbenzonitrile

benzyl bromide

2-chloropyridine