3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine

Base Information

• Chemical Name: 3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine
• CAS No.: 1421822-98-1
• Molecular Formula: C₁₀H₁₀Cl₂N₄S
• Molecular Weight: 289.188
• Mol file: 1421822-98-1.mol

Synonyms:3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine

Chemical Property of 3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine

There total 2 articles about 3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzoic acid hydrazide (536-40-3) → 3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine (1421822-98-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / Cooling

2: hydrazine hydrate monohydrate / methanol / 6 h / Reflux

3: potassium carbonate / acetonitrile

With hydrazine hydrate monohydrate; potassium carbonate; potassium hydroxide; In methanol; acetonitrile;

DOI:10.1039/c2ra21135a

Reference yield:

4-amino-5-mercapto-3-(4-chlorophenyl)-1,2,4-triazole (68468-95-1) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine (1421822-98-1)

Guidance literature:

With potassium carbonate; In acetonitrile;

DOI:10.1039/c2ra21135a

Reference yield: 80.0%

3-aminopropyltriethoxysilane (919-30-2,29159-37-3) + 3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine (1421822-98-1) → 3-(2-((3-aminopropyl)diethoxysilyl)ethylthio)-5-(4-((3-aminopropyl)diethoxy silyl)phenyl)-4H-1,2,4-triazol-4-amine (1421822-99-2)

Guidance literature:

3-aminopropyltriethoxysilane; With iodine; magnesium; In tetrahydrofuran; for 0.5h;

3-(2-chloroethylthio)-5-(4-chlorophenyl)-4H-1,2,4-triazole-4-amine; In tetrahydrofuran; for 10.5h; Reflux;

DOI:10.1039/c2ra21135a

upstream raw materials:

4-amino-5-mercapto-3-(4-chlorophenyl)-1,2,4-triazole

1,2-dichloro-ethane

4-chlorobenzoic acid hydrazide

Downstream raw materials:

3-(2-((3-aminopropyl)diethoxysilyl)ethylthio)-5-(4-((3-aminopropyl)diethoxy silyl)phenyl)-4H-1,2,4-triazol-4-amine