N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide

Base Information

• Chemical Name: N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide
• CAS No.: 1428943-51-4
• Molecular Formula: C₂₆H₂₈N₄O₃
• Molecular Weight: 444.533

Synonyms:N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide

Chemical Property of N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide

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Technology Process of N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide

There total 1 articles about N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + 4-methoxy-benzylamine (2393-23-9) + 4(5)formylimidazole (3034-50-2) + phenylpropyolic acid (637-44-5) → N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide (1428943-51-4)

Guidance literature:

With sodium sulfate; In methanol; at 20 ℃;

DOI:10.1002/ejoc.201901511

Reference yield: 82.0%

N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide (1428943-51-4) → N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide (1428943-69-4)

Guidance literature:

With silver tetrafluoroborate; (triphenylphosphine)gold(I) chloride; In chloroform-d1; at 70 ℃; for 4h;

DOI:10.1021/ol400526a

Reference yield: 68.0%

N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide (1428943-51-4) → (Z)-5-benzylidene-N-(tert-butyl)-7-(4-methoxybenzyl)-6-oxo-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-8-carboxamide

Guidance literature:

With triphenylphosphine; In chloroform; at 20 ℃; Sealed tube;

DOI:10.1002/ejoc.201901511

upstream raw materials:

tert-butylisonitrile

4-methoxy-benzylamine

4⁽⁵⁾formylimidazole

phenylpropyolic acid

Downstream raw materials:

N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide

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