N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide

Base Information

Chemical Name:N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide
CAS No.:1428943-69-4
Molecular Formula:C₂₆H₂₈N₄O₃
Molecular Weight:444.533
Hs Code.:

Synonyms:N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide

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Chemical Property of N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide

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Technology Process of N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide

There total 4 articles about N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1428943-51-4
N-(2-(tert-butylamino)-1-(1H-imidazol-4-yl)-2-oxoethyl)-N-(4-methoxybenzyl)-3-phenylprop-2-ynamide

: 1428943-69-4
N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide

Guidance literature:: With silver tetrafluoroborate; (triphenylphosphine)gold(I) chloride; In chloroform-d1; at 70 ℃; for 4h;
DOI:10.1021/ol400526a

Reference yield:

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 2393-23-9
4-methoxy-benzylamine

: 637-44-5
phenylpropyolic acid

: 1428943-69-4
N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium sulfate / methanol / 20 °C

2: (triphenylphosphine)gold(I) chloride; silver tetrafluoroborate / chloroform-d1 / 4 h / 70 °C

With silver tetrafluoroborate; (triphenylphosphine)gold(I) chloride; sodium sulfate; In methanol; chloroform-d1; 1: |Ugi Condensation;
DOI:10.1021/ol400526a

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 1428943-69-4
N-(tert-butyl)-8-(4-methoxybenzyl)-7-oxo-5-phenyl-8,9-dihydro-7H-imidazo[1,5-a][1,4]diazepine-9-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium sulfate / methanol / 20 °C

2: 1,1,2,2-tetrachloroethane / 24 h / 110 °C / Sealed tube

With sodium sulfate; In methanol; 1,1,2,2-tetrachloroethane; 1: |Ugi Condensation;
DOI:10.1002/ejoc.201901511