diethyl (1-chloro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate

Base Information

• Chemical Name: diethyl (1-chloro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate
• CAS No.: 1441045-96-0
• Molecular Formula: C₁₂H₁₅ClFO₄P
• Molecular Weight: 308.674
• Mol file: 1441045-96-0.mol

Synonyms:diethyl (1-chloro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate

Chemical Property of diethyl (1-chloro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl (1-chloro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate

There total 2 articles about diethyl (1-chloro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-oxo-2-(p-fluorophenyl)ethyl)phosphonic acid diethyl ester (39758-40-2) → diethyl (1-chloro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate (1441045-96-0)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; at 20 ℃; Reflux;

DOI:10.1039/d0ob00379d

Reference yield:

Diethyl methylphosphonate (683-08-9) → diethyl (1-chloro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate (1441045-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

2: sulfuryl dichloride / dichloromethane / 20 °C / Reflux

With sulfuryl dichloride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1039/d0ob00379d

Reference yield: 88.0%

diethyl (1-chloro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate (1441045-96-0) + N-fluorobis(benzenesulfon)imide (133745-75-2) → (S)-diethyl(1-chloro-1-fluoro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate (1441046-53-2)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; C₅₄H₅₃NOP₂Pd⁽²⁺⁾*2CF₃O₃S^(1-); In methanol; at 20 ℃; for 24h; enantioselective reaction;

DOI:10.1016/j.tetlet.2013.04.054

upstream raw materials:

Diethyl methylphosphonate

(2-oxo-2-(p-fluorophenyl)ethyl)phosphonic acid diethyl ester

Downstream raw materials:

(S)-diethyl(1-chloro-1-fluoro-2-(4-fluorophenyl)-2-oxoethyl)phosphonate