3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole

Base Information

• Chemical Name: 3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole
• CAS No.: 51093-44-8
• Molecular Formula: C₁₅H₁₄N₂O
• Molecular Weight: 238.289
• Mol file: 51093-44-8.mol

Synonyms:3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole

Chemical Property of 3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole

There total 11 articles about 3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-methyl-1H-indazole (13436-48-1) + para-iodoanisole (696-62-8) → 3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole (51093-44-8)

Guidance literature:

With 1,10-Phenanthroline; palladium diacetate; caesium carbonate; In toluene; at 160 ℃; for 72h; Sealed tube;

DOI:10.1039/c3sc50184a

Reference yield: 76.0%

4-chloromethoxybenzene (623-12-1) + 1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole (1627722-97-7) → 3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole (51093-44-8)

Guidance literature:

With potassium phosphate; ((2-dicyclohexylphosphino-2',4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2‘-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate); In tert-butyl methyl ether; water; at 100 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1039/c4ra04235b

Reference yield: 72.0%

4-methoxybenzaldehyde dimethylhydrazone (14371-13-2) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → 3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole (51093-44-8)

Guidance literature:

4-methoxybenzaldehyde dimethylhydrazone; With N-chloro-succinimide; In acetonitrile; at 65 ℃; for 1h; Inert atmosphere;

2-(trimethylsilyl)phenyl trifluoromethanesulfonate; With cesium fluoride; In acetonitrile; at 65 ℃; for 10h; Inert atmosphere;

DOI:10.1039/c2ob07117g

upstream raw materials:

4-methoxybenzaldehyde dimethylhydrazone

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

1-methyl-1H-indazole

para-iodoanisole