1627722-97-7

Usage

Class

Boron-containing indazole derivative

Usage

Pharmaceutical research and drug development

Unique property

Contains a boron atom bonded to a dioxaborolane group

Potential applications

Medicinal chemistry, development of new pharmaceuticals

Current status

Biological and pharmacological activities are being investigated

Promise

Valuable tool in development of new drugs and therapeutic agents

Additional research needed

To fully understand potential applications in science and medicine.

Upstream product

• 52088-10-5 3-iodo-1-methyl-1H-indazole 
• 73183-34-3 bis(pinacol)diborane 
• 13436-48-1 1-methyl-1H-indazole 

Downstream Products

• 51093-42-6 1‐methyl‐3‐phenyl‐1H‐indazole 
• 1632032-34-8 C₁₈H₂₀N₂ 
• 51093-44-8 3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole 
• 1632032-35-9 C₁₆H₁₆N₂O₂ 
• 680612-97-9 4-(1-methyl-1H-indazol-3-yl)phenol 

Relevant academic research and scientific papers

Multidirectional Synthesis of Substituted Indazoles via Iridium-Catalyzed C-H Borylation

In the absence of a steric directing group, iridium-catalyzed C-H borylation of N-protected indazoles occurs rapidly and selectively at C-3 and the resulting boronate esters can be utilized in a range of downstream conversions. The functional group tolera

Pyrimidine or triazine derivative, and preparation method and use thereof

The invention relates to an arylaminopyrimidine or triazine derivative, and a preparation method, a medicinal composition and a use thereof, and concretely relates to a compound represented by formula I, or a pharmaceutically acceptable salt or a solvate thereof. In the formula I, R1 to R7, X and Y are defined in the description and claims. The invention also relates to a preparation method of the compound of formula I, the medicinal composition containing the compound, and the pharmacy use of the compound and the medicinal composition. The compound of formula I is an effective tyrosine kinase irreversible inhibitor, and especially has a strong inhibition effect on EGFR-T790M drug-resistant tumors.

Synthesis of 3-aryl-1H-indazoles via iridium-catalysed C-H borylation and Suzuki-Miyaura coupling

The regioselective iridium-catalysed C3-borylation of 1H-indazoles has been achieved. Subsequent Suzuki-Miyaura coupling of the boronate esters with aryl chlorides, bromides and iodides affords 3-aryl-1H-indazoles in good yields. This journal is the Partn

BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME

Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.