2,2-dibromo-1-(4-cyanophenyl)ethan-1-one

Base Information

• Chemical Name: 2,2-dibromo-1-(4-cyanophenyl)ethan-1-one
• CAS No.: 21661-87-0
• Molecular Formula: C₉H₅Br₂NO
• Molecular Weight: 302.953
• Mol file: 21661-87-0.mol

Synonyms:2,2-dibromo-1-(4-cyanophenyl)ethan-1-one

Chemical Property of 2,2-dibromo-1-(4-cyanophenyl)ethan-1-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-dibromo-1-(4-cyanophenyl)ethan-1-one

There total 9 articles about 2,2-dibromo-1-(4-cyanophenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(4-cyanophenyl)-N-methoxy-N-methylformamide (116332-64-0) + 1,1-dibromomethane (74-95-3) → 2,2-dibromo-1-(4-cyanophenyl)ethan-1-one (21661-87-0)

Guidance literature:

With methyllithium lithium bromide; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/adsc.202001106

Reference yield: 87.0%

4-(2,2,2-tribromoacetyl)benzonitrile → 2,2-dibromo-1-(4-cyanophenyl)ethan-1-one (21661-87-0)

Guidance literature:

With water; hydrogen bromide; In tetrahydrofuran; at 80 ℃;

DOI:10.1002/ejoc.202001118

Reference yield: 82.0%

4-cyanophenylacetylene (3032-92-6) → 2,2-dibromo-1-(4-cyanophenyl)ethan-1-one (21661-87-0)

Guidance literature:

With sodium hydrogensulfate monohydrate; water; sodium bromide; In acetonitrile; at 20 ℃; for 8h; Schlenk technique;

DOI:10.1039/c9cc07655g

upstream raw materials:

methanol

4-cyanophenyl methyl ketone

4-ethylbenzonitrile

4-cyanophenylacetylene

Downstream raw materials:

3-(4-cyanobenzoylformamido)-4-(4-cyanophenyl)-1,2,5-thiadiazole

4-(2-(dimethylamino)-1,3-selenazol-4-yl)benzonitrile