116332-64-0

Basic information

• Product Name: 4-CYANO-N-METHOXY-N-METHYLBENZAMIDE
• Synonyms: 4-CYANO-N-METHOXY-N-METHYLBENZAMIDE;4-CYANO-N-METHOXY-N-METHYLBENZENECARBOXAMIDE;4-[Methoxy(methyl)carbamoyl]benzonitrile
• CAS NO: 116332-64-0
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.2
• Mol File: 116332-64-0.mol
• Article Data: 20

Chemical Properties

• Melting Point: 78-80
• Boiling Point: 383.3 °C at 760 mmHg
• Flash Point: 185.6 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 4.43E-06mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-CYANO-N-METHOXY-N-METHYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYANO-N-METHOXY-N-METHYLBENZAMIDE(116332-64-0)
• EPA Substance Registry System: 4-CYANO-N-METHOXY-N-METHYLBENZAMIDE(116332-64-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 116332-64-0(Hazardous Substances Data)

Usage

General Description

4-Cyano-N-methoxy-N-methylbenzamide is a chemical compound with the molecular formula C10H11N3O2. It is a benzamide derivative with a cyano group and a methoxy group attached to the benzene ring. 4-CYANO-N-METHOXY-N-METHYLBENZAMIDE is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It may also have potential applications in medicinal chemistry and drug development. The properties and uses of 4-Cyano-N-methoxy-N-methylbenzamide make it a valuable component in chemical synthesis and research.

InChI:InChI=1/C10H10N2O2/c1-12(14-2)10(13)9-5-3-8(7-11)4-6-9/h3-6H,1-2H3

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 201230-82-2 carbon monoxide 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 623-00-7 4-bromobenzenecarbonitrile 
• 6068-72-0 4-cyanobenzoyl chlorIde 
• 13939-06-5 molybdenum hexacarbonyl 
• 626201-15-8 4-cyanophenyl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 619-65-8 4-cyanobenzoic Acid 
• 3058-39-7 4-iodobenzonitrile 
• 1117-97-1 N,0-dimethylhydroxylamine 

Downstream Products

• 1202376-71-3 4-(4-methyl-4-(trimethylsilyloxy)pent-2-ynoyl)benzonitrile 
• 69677-75-4 (4-benzoylphenyl)(p-tolyl)methanone 
• 20912-50-9 4-benzoylbenzaldehyde 
• 60694-99-7 1-(4-cyanophenyl)-2-phenylethan-1-one 
• 21661-87-0 2,2-dibromo-1-(4-cyanophenyl)ethan-1-one 
• 79784-60-4 p-cyano-γ-methylvalerophenone 
• 1202368-47-5 4-(5,5-dimethyl-4-oxo-3-(4-(quinolin-2-ylmethoxy)phenyl)-4,5-dihydrofuran-2-yl)benzonitrile 
• 1202376-74-6 4-(3-bromo-5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzonitrile 
• 1202376-72-4 4-(4-hydroxy-4-methylpent-2-ynoyl)benzonitrile 
• 1202376-73-5 4-(5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)benzonitrile 
• 874-89-5 4-Cyanobenzyl alcohol 

Relevant articles and documents

Iron-Catalyzed, Iminyl Radical-Triggered Cascade 1,5-Hydrogen Atom Transfer/(5+2) or (5+1) Annulation: Oxime as a Five-Atom Assembling Unit

By integration of iminyl radical-triggered 1,5-hydrogen atom transfer and (5+2) or (5+1) annulation processes, a series of structurally novel and interesting azepine and spiro-tetrahydropyridine derivatives have been successfully prepared in moderate to good yields. This method utilizes FeCl2 as the catalyst and readily available oximes as five-atom units, while showcasing broad substrate scope and good functional group compatibility. The annulation products can be easily converted into many valuable compounds. Moreover, DFT calculation studies are performed to provide some insights into the possible reaction mechanisms for the (5+2) and (5+1) annulations.

Magnesium Aldimines Prepared by Addition of Organomagnesium Halides to 2,4,6-Trichlorophenyl Isocyanide: Synthesis of 1,2-Dicarbonyl Derivatives

The selective addition of organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide leading to magnesiated aldimines is reported. These aldimines react with Weinreb amides, ketones, or carbonates to provide the corresponding carbonyl derivatives after acidic cleavage. This allows for an efficient synthesis of 1,2-dicarbonyl compounds and α-hydroxy ketones.

Mo(CO)6 as a Solid CO Source in the Synthesis of Aryl/Heteroaryl Weinreb Amides under Microwave-Enhanced Condition

The facile transformation of aryl/heteroaryl nonaflates into corresponding amides via Pd-catalyzed aminocarbonylation using Mo(CO)6 as a solid CO source under microwave-enhanced condition is reported. The method was found to be tolerant with respect to a