3-(3-Bromophenyl)-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-(3-Bromophenyl)-2,2-dimethylpropanoic acid
CAS No.:926625-06-1
Molecular Formula:C₁₁H₁₃BrO₂
Molecular Weight:257.127
Hs Code.:
DSSTox Substance ID:DTXSID801272507

Synonyms:3-(3-bromophenyl)-2,2-dimethylpropanoic acid;926625-06-1;3-(3-Bromophenyl)-2,2-dimethylpropanoicacid;SCHEMBL23123860;DTXSID801272507;BMB62506;AKOS012032976;BS-47950;CS-0197516;C90966;EN300-1218135;F2147-6175

Suppliers and Price of 3-(3-Bromophenyl)-2,2-dimethylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-(3-Bromophenyl)-2,2-dimethylpropanoic acid

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:256.00989
Heavy Atom Count:14
Complexity:213

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(CC1=CC(=CC=C1)Br)C(=O)O

Technology Process of 3-(3-Bromophenyl)-2,2-dimethylpropanoic acid

There total 2 articles about 3-(3-Bromophenyl)-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 823-78-9
meta-bromobenzyl bromide

: 926625-06-1
3-(3-bromophenyl)-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: 10.2 g / tetrahydrofuran / -78 - 20 °C

2.1: 95 percent / KOH / H₂O; methanol / Heating

With potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo061127v

Reference yield:

: 591-17-3
meta-bromotoluene

: 926625-06-1
3-(3-bromophenyl)-2,2-dimethylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: NBS; AIBN / benzene / 10 h / Heating

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 10.2 g / tetrahydrofuran / -78 - 20 °C

3.1: 95 percent / KOH / H₂O; methanol / Heating

With potassium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); lithium diisopropyl amide; In tetrahydrofuran; methanol; water; benzene;
DOI:10.1021/jo061127v

Reference yield: 72.0%

: 926625-06-1
3-(3-bromophenyl)-2,2-dimethylpropionic acid

: 67-56-1
methanol

: methyl (1-(3-bromophenyl)-2-methylpropan-2-yl)carbamate

Guidance literature:: 3-(3-bromophenyl)-2,2-dimethylpropionic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 100 ℃; for 2h;

methanol; In toluene; at 100 ℃; for 16h;