N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide

Base Information

Chemical Name:N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide
CAS No.:1198181-28-0
Molecular Formula:C₁₄H₁₇F₃N₂O₂
Molecular Weight:302.296
Hs Code.:

Synonyms:N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide

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Chemical Property of N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide

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Technology Process of N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide

There total 2 articles about N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 453560-57-1
N-(3-bromo-5-trifluoromethyl-phenyl)-acetamide

: 1198181-28-0
N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C

1.2: 16 h / 20 °C

2.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 85 °C / Inert atmosphere

With sodium hydride; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 54962-75-3
[3-bromo-5-(trifluoromethyl)phenyl]amine

: 1198181-28-0
N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 16 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 16 h / 85 °C / Inert atmosphere

With pyridine; sodium hydride; caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1198181-28-0
N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide

: 3926-62-3
sodium monochloroacetic acid

: C₁₆H₁₉F₃N₂O₄

Guidance literature:: N-[3-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)phenyl]-N-methylacetamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 60 ℃;

sodium monochloroacetic acid; With tetrabutylammomium bromide; In N,N-dimethyl-formamide; mineral oil; at 60 ℃; for 1h;

With hydrogenchloride; In water;