tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane
CAS No.:750594-52-6
Molecular Formula:C₂₃H₄₆OSi
Molecular Weight:366.703
Hs Code.:

Synonyms:tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane

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Chemical Property of tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane

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Technology Process of tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane

There total 5 articles about tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 594-19-4
tert.-butyl lithium

: 750594-50-4
Carbonic acid (1R,2S,5R)-1-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-2-isopropyl-5-methyl-cyclohexyl ester methyl ester

: 750594-52-6
tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane

Guidance literature:: tert.-butyl lithium; With CuCN; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

Carbonic acid (1R,2S,5R)-1-[(E)-3-(tert-butyl-dimethyl-silanyloxy)-propenyl]-2-isopropyl-5-methyl-cyclohexyl ester methyl ester; In tetrahydrofuran; pentane; at -78 - 20 ℃; for 4h;
DOI:10.1021/ol048936q

Reference yield:

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 750594-52-6
tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1.1: biscyclopentadienylzirconium dichloride; lithium triethylborohydride / tetrahydrofuran / 2 h / 20 °C

1.2: 69 percent / I₂ / tetrahydrofuran / 10 h / 20 °C

2.1: t-BuLi; CeCl₃ / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 73 percent / tetrahydrofuran; pentane / 1 h / -78 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

3.2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C

4.1: CuCN / tetrahydrofuran; pentane / 0.5 h / -78 °C

4.2: 1.09 g / tetrahydrofuran; pentane / 4 h / -78 - 20 °C

With n-butyllithium; cerium(III) chloride; zirconocene dichloride; tert.-butyl lithium; lithium triethylborohydride; In tetrahydrofuran; hexane; pentane;
DOI:10.1021/ol048936q

Reference yield:

: 116381-84-1
(E)-1-tert-butyldimethylsilyloxy-3-iodo-2-propene

: 750594-52-6
tert-Butyl-{(S)-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-3,3-dimethyl-butoxy}-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuLi; CeCl₃ / tetrahydrofuran; pentane / 1 h / -78 °C

1.2: 73 percent / tetrahydrofuran; pentane / 1 h / -78 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 - 0 °C

2.2: tetrahydrofuran; hexane / 2 h / 0 - 20 °C

3.1: CuCN / tetrahydrofuran; pentane / 0.5 h / -78 °C

3.2: 1.09 g / tetrahydrofuran; pentane / 4 h / -78 - 20 °C

With n-butyllithium; cerium(III) chloride; tert.-butyl lithium; In tetrahydrofuran; hexane; pentane;
DOI:10.1021/ol048936q