1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine p-toluenesulfonate

Base Information

Chemical Name:1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine p-toluenesulfonate
CAS No.:76227-24-2
Molecular Formula:C₇H₈O₃S*C₁₁H₁₇N₅O₄
Molecular Weight:455.492
Hs Code.:

Synonyms:1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine p-toluenesulfonate

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Chemical Property of 1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine p-toluenesulfonate

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Technology Process of 1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine p-toluenesulfonate

There total 5 articles about 1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-15-4
toluene-4-sulfonic acid

: 76227-22-0
N-Benzyloxy-5-(formyl-methyl-amino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-imidazole-4-carboxamidine

: 76227-24-2
1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine p-toluenesulfonate

Guidance literature:: With hydrogen; nickel; In water; for 1.5h; under 760 Torr; Ambient temperature;
DOI:10.1039/c39800000758

Reference yield:

: 3506-01-2
2'-Deoxyadenosine N¹-oxide

: 76227-24-2
1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine p-toluenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / NaClO₄ / N,N-dimethyl-acetamide

2: 70 percent / Amberlite IRA-402 (HCO₃^-), H₂O / 192 h / 3 - 4 °C

3: 69 percent / K₂CO₃ / dimethylformamide / Ambient temperature

4: H₂ / Raney Ni / H₂O / 1.5 h / 760 Torr / Ambient temperature

With Amberlite IRA-402 (HCO₃^-); sodium perchlorate; water; hydrogen; potassium carbonate; nickel; In N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
DOI:10.1039/c39800000758

Reference yield:

: 76227-21-9
N'-benzyloxy-1-(2-deoxy-β-D-ribofuranosyl)-5-formamido-1H-imidazole-4-carboxamidine

: 76227-24-2
1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine p-toluenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / K₂CO₃ / dimethylformamide / 5 h / Ambient temperature

2: 910 mg / H₂ / Raney Ni W-2 / H₂O / 1.17 h / Ambient temperature

With hydrogen; potassium carbonate; Raney Ni W-2; In water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.2601