N-Benzyloxy-5-(formyl-methyl-amino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-imidazole-4-carboxamidine

Base Information

Chemical Name:N-Benzyloxy-5-(formyl-methyl-amino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-imidazole-4-carboxamidine
CAS No.:76227-22-0
Molecular Formula:C₁₈H₂₃N₅O₅
Molecular Weight:389.411
Hs Code.:

Synonyms:N-Benzyloxy-5-(formyl-methyl-amino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-imidazole-4-carboxamidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Benzyloxy-5-(formyl-methyl-amino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-imidazole-4-carboxamidine

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Technology Process of N-Benzyloxy-5-(formyl-methyl-amino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-imidazole-4-carboxamidine

There total 7 articles about N-Benzyloxy-5-(formyl-methyl-amino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-imidazole-4-carboxamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 76227-21-9
N'-benzyloxy-1-(2-deoxy-β-D-ribofuranosyl)-5-formamido-1H-imidazole-4-carboxamidine

: 74-88-4
methyl iodide

: 76227-22-0
N'-benzyloxy-1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 5h; Ambient temperature;
DOI:10.1248/cpb.37.2601

Reference yield: 69.0%

: 76227-21-9
N'-benzyloxy-1-(2-deoxy-β-D-ribofuranosyl)-5-formamidoimidazole-4-carboxamidine

: 74-88-4
methyl iodide

: 76227-22-0
N-Benzyloxy-5-(formyl-methyl-amino)-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-imidazole-4-carboxamidine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1039/c39800000758

Reference yield:

: 3506-01-2
2'-Deoxyadenosine N¹-oxide

: 76227-22-0
N'-benzyloxy-1-(2-deoxy-β-D-ribofuranosyl)-5-(N-methylformamido)-1H-imidazole-4-carboxamidine

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / AcNMe₂ / 4 h / Ambient temperature; 2.) H₂O, HClO₄

2: 70 percent / Amberlite IRA-402 (HClO₃^-) / H₂O

3: 70 percent / K₂CO₃ / dimethylformamide / 5 h / Ambient temperature

With N,N-dimethyl acetamide; Amberlite IRA-402 (HClO₃^-); potassium carbonate; In water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.2601