isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

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Chemical Name:isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate
CAS No.:1374344-60-1
Molecular Formula:C₂₁H₂₀F₂N₈O₂
Molecular Weight:454.439
Hs Code.:

Synonyms:isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

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Chemical Property of isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

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Technology Process of isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

There total 8 articles about isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1374344-83-8
2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidine-4,5,6-triamine

: 108-23-6
isopropyl chloroformate

: 1374344-60-1
isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: With pyridine; at 0 ℃; for 1h;

Reference yield: 24.0%

: 1374344-60-1
isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: With pyridine; at 0 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1361570-32-2
1-(3,5-difluoropyridin-2-yl)-2-(2-fluorophenyl)ethanone

: 1374344-60-1
isopropyl {4,6-diamino-2-[6-fluoro-3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]pyrimidin-5-yl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; hydrazine hydrate; dmap / 0.5 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 20 °C

2.2: 1 h / 80 °C

3.1: hydrogen; palladium 10% on activated carbon / pyridine

4.1: pyridine / 1 h / 0 °C

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; sodium hydride; hydrazine hydrate; In pyridine; N,N-dimethyl-formamide; mineral oil;