t-butyl (1S,2R,3S)-N-benzyl-N-<3-t-butyldimethylsiloxy-1-(E)-styryl-2-(triethylsiloxy)methylbutyl>carbamate

Base Information

Chemical Name:t-butyl (1S,2R,3S)-N-benzyl-N-<3-t-butyldimethylsiloxy-1-(E)-styryl-2-(triethylsiloxy)methylbutyl>carbamate
CAS No.:142065-12-1
Molecular Formula:C₃₇H₆₁NO₄Si₂
Molecular Weight:640.067
Hs Code.:

Synonyms:t-butyl (1S,2R,3S)-N-benzyl-N-<3-t-butyldimethylsiloxy-1-(E)-styryl-2-(triethylsiloxy)methylbutyl>carbamate

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Chemical Property of t-butyl (1S,2R,3S)-N-benzyl-N-<3-t-butyldimethylsiloxy-1-(E)-styryl-2-(triethylsiloxy)methylbutyl>carbamate

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Technology Process of t-butyl (1S,2R,3S)-N-benzyl-N-<3-t-butyldimethylsiloxy-1-(E)-styryl-2-(triethylsiloxy)methylbutyl>carbamate

There total 12 articles about t-butyl (1S,2R,3S)-N-benzyl-N-<3-t-butyldimethylsiloxy-1-(E)-styryl-2-(triethylsiloxy)methylbutyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 142065-10-9
Benzyl-[(1S,2R,3S)-3-(tert-butyl-dimethyl-silanyloxy)-1-((E)-styryl)-2-triethylsilanyloxymethyl-butyl]-amine

: 142065-12-1
t-butyl (1S,2R,3S)-N-benzyl-N-<3-t-butyldimethylsiloxy-1-(E)-styryl-2-(triethylsiloxy)methylbutyl>carbamate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 4.5h;
DOI:10.1246/bcsj.68.2103

Reference yield:

: 142039-68-7
(E)-(2R,3S)-3-Benzylamino-2-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pent-4-en-1-ol

: 142065-12-1
t-butyl (1S,2R,3S)-N-benzyl-N-<3-t-butyldimethylsiloxy-1-(E)-styryl-2-(triethylsiloxy)methylbutyl>carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / imidazole / CH₂Cl₂ / 1 h / Ambient temperature

2: 61 percent / Et₃N / dimethylformamide / 4.5 h / 50 °C

With 1H-imidazole; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.68.2103

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 142065-12-1
t-butyl (1S,2R,3S)-N-benzyl-N-<3-t-butyldimethylsiloxy-1-(E)-styryl-2-(triethylsiloxy)methylbutyl>carbamate

Guidance literature:: Multi-step reaction with 4 steps

2: 60 percent / LAH

With lithium aluminium tetrahydride;
DOI:10.1021/ja00039a066