C₁₈H₁₆N₄O

Base Information

Chemical Name:C₁₈H₁₆N₄O
CAS No.:952303-63-8
Molecular Formula:C₁₈H₁₆N₄O
Molecular Weight:304.351
Hs Code.:

C<sub>18</sub>H<sub>16</sub>N<sub>4</sub>O

Synonyms:C₁₈H₁₆N₄O

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Chemical Property of C₁₈H₁₆N₄O

Chemical Property:

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Technology Process of C₁₈H₁₆N₄O

There total 14 articles about C₁₈H₁₆N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: C₂₂H₂₄N₄O

: 952303-63-8
C₁₈H₁₆N₄O

Guidance literature:: With potassium hydrogensulfate; sodium azide; In dichloromethane; water; at 20 ℃; for 12h;
DOI:10.1021/jo070774z

Reference yield:

: 952303-56-9
2-(4-bromo-2,5-dimethylbenzyl)malonic acid diethyl ester

: 952303-63-8
C₁₈H₁₆N₄O

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / H₂O / 5 h / Heating

1.2: 83 percent / sulfuric acid / H₂O / 20 h / Heating

2.1: 88 percent / polyphosphoric acid / 2.5 h / 100 °C

3.1: 98 percent / sodium borohydride / ethanol / 1 h / 0 - 20 °C

4.1: 86 percent / p-toluenesulfonic acid / benzene / 2 h / Heating

5.1: ozone / methanol; CH₂Cl₂ / -78 °C

5.2: dimethyl sulfide; sodium hydrogen carbonate / methanol; CH₂Cl₂ / 4 h / 20 °C

6.1: 101 mg / aq. NH₃ / CH₂Cl₂; methanol / 12 h / 20 °C

7.1: i-PrMgCl*LiCl / tetrahydrofuran / 1.2 h / -20 - -10 °C

7.2: ZnBr₂ / tetrahydrofuran / 0.5 h / -10 - -5 °C

7.3: 63 percent / Pd(PPh₃)4 / tetrahydrofuran / 5 h / Heating

8.1: 94 percent / potassium hydrogen sulfate; sodium azide / CH₂Cl₂; H₂O / 12 h / 20 °C

With potassium hydroxide; ammonium hydroxide; sodium tetrahydroborate; potassium hydrogensulfate; TurboGrignard; sodium azide; PPA; toluene-4-sulfonic acid; ozone; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; benzene; 7.3: Negishi cross-coupling;
DOI:10.1021/jo070774z

Reference yield:

: 952303-57-0
6-bromo-4,7-dimethylindan-1-one

: 952303-63-8
C₁₈H₁₆N₄O

Guidance literature:: Multi-step reaction with 6 steps

1.1: 98 percent / sodium borohydride / ethanol / 1 h / 0 - 20 °C

2.1: 86 percent / p-toluenesulfonic acid / benzene / 2 h / Heating

3.1: ozone / methanol; CH₂Cl₂ / -78 °C

3.2: dimethyl sulfide; sodium hydrogen carbonate / methanol; CH₂Cl₂ / 4 h / 20 °C

4.1: 101 mg / aq. NH₃ / CH₂Cl₂; methanol / 12 h / 20 °C

5.1: i-PrMgCl*LiCl / tetrahydrofuran / 1.2 h / -20 - -10 °C

5.2: ZnBr₂ / tetrahydrofuran / 0.5 h / -10 - -5 °C

5.3: 63 percent / Pd(PPh₃)4 / tetrahydrofuran / 5 h / Heating

6.1: 94 percent / potassium hydrogen sulfate; sodium azide / CH₂Cl₂; H₂O / 12 h / 20 °C

With ammonium hydroxide; sodium tetrahydroborate; potassium hydrogensulfate; TurboGrignard; sodium azide; toluene-4-sulfonic acid; ozone; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; benzene; 5.3: Negishi cross-coupling;
DOI:10.1021/jo070774z