(1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

Base Information

Chemical Name:(1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one
CAS No.:262279-86-7
Molecular Formula:C₁₅H₁₆BrNO₃
Molecular Weight:338.201
Hs Code.:
Mol file:262279-86-7.mol

Synonyms:(1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

Suppliers and Price of (1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

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Technology Process of (1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

There total 1 articles about (1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 64-19-7,77671-22-8
acetic acid

: 103065-89-0
(1R,4S)-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

: 262279-86-7
(1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

Guidance literature:: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; at 20 ℃;
DOI:10.1021/jm9904755

Reference yield: 99.0%

: 262279-86-7
(1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

: 262279-88-9
(1R,4R,6S,7R)-7-bromo-6-hydroxy-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

Guidance literature:: With potassium carbonate; In methanol; for 2h;
DOI:10.1021/jm9904755

Reference yield:

: 262279-86-7
(1R,4R,6S,7R)-6-acetoxy-7-bromo-2-benzyl-2-azabicyclo[2.2.1]heptan-3-one

: 262279-92-5
(1S,4R,6S)-2-benzyl-6-fluoro-2-azabicyclo[2.2.1]heptan-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / aq. K₂CO₃ / methanol / 2 h

2: 88 percent / (diethylamino)sulfur trifluoride / CH₂Cl₂ / 10.5 h / -80 - 20 °C

3: 94 percent / tributyltin hydride; 2,2'-azobisisobutyronitrile / benzene / 12 h / Heating

With 2,2'-azobis(isobutyronitrile); diethylamino-sulfur trifluoride; tri-n-butyl-tin hydride; potassium carbonate; In methanol; dichloromethane; benzene; 1: Hydrolysis / 2: Fluorination / 3: Debromination;
DOI:10.1021/jm9904755