2',3'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin

Base Information

• Chemical Name: 2',3'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin
• CAS No.: 79974-73-5
• Molecular Formula: C₄₁H₅₈N₂O₇Si₂
• Molecular Weight: 747.092
• Mol file: 79974-73-5.mol

Synonyms:2',3'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin

Chemical Property of 2',3'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin

There total 3 articles about 2',3'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 5,6-Dihydro-5'-O-(4-methoxytrityl)uridin (79974-71-3) → 2'-O-t-Butyldimethylsilyl-5'-O-monomethoxytrityl-N6-benzoyl-5,6-dihydro-uridin (79536-96-2) + 3'-O-(tert-Butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin (79974-72-4) + 2',3'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin (79974-73-5)

Guidance literature:

With 1H-imidazole; In dimethyl sulfoxide; N,N-dimethyl-formamide; 1) 1 h, 0 deg C, 2) 18 h, room temperature;

Reference yield:

5,6-dihydrouridine (5627-05-4) → 2',3'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin (79974-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / pyridine / 48 h / Ambient temperature

2: 22 percent / imidazol / dimethylformamide; dimethylsulfoxide / 1) 1 h, 0 deg C, 2) 18 h, room temperature

With 1H-imidazole; In pyridine; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

uridine (58-96-8) → 2',3'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5'-O-(4-methoxytrityl)uridin (79974-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / H₂ / Rh/C(5percent) / H₂O / 24 h

2: 68 percent / pyridine / 48 h / Ambient temperature

3: 22 percent / imidazol / dimethylformamide; dimethylsulfoxide / 1) 1 h, 0 deg C, 2) 18 h, room temperature

With 1H-imidazole; hydrogen; rhodium contaminated with carbon; In pyridine; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyldimethylsilyl chloride

5,6-Dihydro-5'-O-(4-methoxytrityl)uridin

5,6-dihydrouridine

uridine