6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid

Base Information

Chemical Name:6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid
CAS No.:1323264-35-2
Molecular Formula:C₂₀H₂₁N₃O₈S
Molecular Weight:463.468
Hs Code.:

Synonyms:6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid

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Chemical Property of 6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid

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Technology Process of 6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid

There total 7 articles about 6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1323264-34-1
dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate

: 1323264-35-2
6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid

Guidance literature:: With potassium hydroxide; In methanol; dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1135/cccc2011017

Reference yield:

: 138-60-3
chelidamic acid

: 1323264-35-2
6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentabromide / chloroform / 3 h / 90 °C / Inert atmosphere

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.2: 0.17 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

5.1: potassium hydroxide / methanol; dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; phosphorus pentabromide; triethylamine; 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1135/cccc2011017

Reference yield:

: 1323264-30-7
dimethyl 4-[(1-tert-butoxycarbonylpiperidin-4-yl)methyl]pyridine-2,6-dicarboxylate

: 1323264-35-2
6-methoxycarbonyl-4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: potassium hydroxide / methanol; dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With dmap; triethylamine; trifluoroacetic acid; potassium hydroxide; In methanol; dichloromethane;
DOI:10.1135/cccc2011017