4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine

Base Information

Chemical Name:4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine
CAS No.:1323264-42-1
Molecular Formula:C₃₃H₄₈N₆O₈S
Molecular Weight:688.846
Hs Code.:

4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine

Synonyms:4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine

Suppliers and Price of 4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine

There total 10 articles about 4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: C₂₄H₃₂N₄O₉S₂

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1323264-42-1
4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃; for 16h;
DOI:10.1135/cccc2011017

Reference yield:

: 1323264-30-7
dimethyl 4-[(1-tert-butoxycarbonylpiperidin-4-yl)methyl]pyridine-2,6-dicarboxylate

: 1323264-42-1
4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

3: potassium hydroxide / methanol; dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

4: diphenyl phosphoryl azide; triethylamine / toluene / 16 h / 100 °C / Inert atmosphere

5: sodium tetrahydroborate; calcium chloride / ethanol / 2 h / 0 °C / Inert atmosphere

6: triethylamine / ethyl acetate / 1 h / 0 °C / Inert atmosphere

7: potassium carbonate / acetonitrile / 16 h / 20 °C

With dmap; sodium tetrahydroborate; diphenyl phosphoryl azide; potassium carbonate; triethylamine; trifluoroacetic acid; calcium chloride; potassium hydroxide; In methanol; ethanol; dichloromethane; ethyl acetate; toluene; acetonitrile; 4: Curtius rearrangement;
DOI:10.1135/cccc2011017

Reference yield:

: 1323264-31-8
C₁₅H₂₀N₂O₄

: 1323264-42-1
4-tert-butoxycarbonylamino-1-[6-tert-butoxycarbonylamino-4-([{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridin-2-yl]methyl)]piperidine

Guidance literature:: Multi-step reaction with 6 steps

1: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: potassium hydroxide / methanol; dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

3: diphenyl phosphoryl azide; triethylamine / toluene / 16 h / 100 °C / Inert atmosphere

4: sodium tetrahydroborate; calcium chloride / ethanol / 2 h / 0 °C / Inert atmosphere

5: triethylamine / ethyl acetate / 1 h / 0 °C / Inert atmosphere

6: potassium carbonate / acetonitrile / 16 h / 20 °C

With dmap; sodium tetrahydroborate; diphenyl phosphoryl azide; potassium carbonate; triethylamine; calcium chloride; potassium hydroxide; In methanol; ethanol; dichloromethane; ethyl acetate; toluene; acetonitrile; 3: Curtius rearrangement;
DOI:10.1135/cccc2011017