dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate

Base Information

Chemical Name:dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate
CAS No.:1323264-34-1
Molecular Formula:C₂₁H₂₃N₃O₈S
Molecular Weight:477.495
Hs Code.:

Synonyms:dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate

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Chemical Property of dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate

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Technology Process of dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate

There total 7 articles about dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1323264-48-7
4-methylene-1-(2-nitrophenylsulfonyl)piperidine

: 162102-79-6
dimethyl 4-bromo-2,6-pyridinedicarboxylate

: 1323264-34-1
dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate

Guidance literature:: 4-methylene-1-(2-nitrophenylsulfonyl)piperidine; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; for 1h; Reflux; Inert atmosphere;

dimethyl 4-bromo-2,6-pyridinedicarboxylate; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1135/cccc2011017

Reference yield:

: 1323264-31-8
C₁₅H₂₀N₂O₄

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1323264-34-1
dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1135/cccc2011017

Reference yield:

: 138-60-3
chelidamic acid

: 1323264-34-1
dimethyl 4-{[1-(2-nitrobenzenesulfonyl)piperidin-4-yl]methyl}pyridine-2,6-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: phosphorus pentabromide / chloroform / 3 h / 90 °C / Inert atmosphere

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.2: 0.17 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

4.1: dmap; triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With dmap; phosphorus pentabromide; triethylamine; 9-bora-bicyclo[3.3.1]nonane; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1135/cccc2011017