3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[4,3-c]pyridine

Base Information

Chemical Name:3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[4,3-c]pyridine
CAS No.:1049809-91-7
Molecular Formula:C₁₂H₁₁ClIN₃
Molecular Weight:359.597
Hs Code.:

Synonyms:3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[4,3-c]pyridine

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Chemical Property of 3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[4,3-c]pyridine

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Technology Process of 3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[4,3-c]pyridine

There total 5 articles about 3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1049809-51-9
3-(4-chloro-3-iodo-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]-pyridine-5-carboxylic acid tert-butyl ester

: 1049809-91-7
3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[4,3-c]pyridine

Guidance literature:: 3-(4-chloro-3-iodo-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]-pyridine-5-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16.3333h;

With sodium hydroxide; In dichloromethane; water; for 3h; pH=> 12;

Reference yield:

: 42860-04-8
4-chloro-3-iodobenzoic acid

: 1049809-91-7
3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 3 - 17 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

2.2: 16.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 16.33 h / 20 °C

3.2: 3 h / pH > 12

With oxalyl dichloride; triethylamine; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 217807-98-2
4-morpholin-4-yl-3,6-dihydro-2H-pyridine-1-carboxylic acid ter-tbutyl ester

: 1049809-91-7
3-(4-chloro-3-iodo-phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo-[4,3-c]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

1.2: 16.5 h / 0 - 20 °C

2.1: trifluoroacetic acid / dichloromethane / 16.33 h / 20 °C

2.2: 3 h / pH > 12

With triethylamine; trifluoroacetic acid; In dichloromethane;