1-(4-Chlorophenyl)-1,3-dihydro-3-(phenylthio)2H-pyrrolo[2,3-b]pyridin-2-one

Base Information

Chemical Name:1-(4-Chlorophenyl)-1,3-dihydro-3-(phenylthio)2H-pyrrolo[2,3-b]pyridin-2-one
CAS No.:127555-68-4
Molecular Formula:C₁₉H₁₃ClN₂OS
Molecular Weight:352.844
Hs Code.:

Synonyms:1-(4-Chlorophenyl)-1,3-dihydro-3-(phenylthio)2H-pyrrolo[2,3-b]pyridin-2-one

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Chemical Property of 1-(4-Chlorophenyl)-1,3-dihydro-3-(phenylthio)2H-pyrrolo[2,3-b]pyridin-2-one

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Technology Process of 1-(4-Chlorophenyl)-1,3-dihydro-3-(phenylthio)2H-pyrrolo[2,3-b]pyridin-2-one

There total 6 articles about 1-(4-Chlorophenyl)-1,3-dihydro-3-(phenylthio)2H-pyrrolo[2,3-b]pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-38-9,18923-20-1
carbon dioxide

: 144-55-8
sodium hydrogencarbonate

: 127555-67-3
N-(4-chlorophenyl)-3-[(phenylthio)methyl]-2-pyridinamine

: 127555-68-4
1-(4-Chlorophenyl)-1,3-dihydro-3-(phenylthio)2H-pyrrolo[2,3-b]pyridin-2-one

Guidance literature:: With hydrogenchloride; n-butyllithium; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; water;

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 127555-68-4
1-(4-Chlorophenyl)-1,3-dihydro-3-(phenylthio)2H-pyrrolo[2,3-b]pyridin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine, p-TsOH / H₂O / Heating

2: 97 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

3: SOCl₂ / CH₂Cl₂ / 16 h / Ambient temperature

4: NaOH / ethanol; H₂O / 16 h / Ambient temperature

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00172a004

Reference yield:

: 16344-26-6
2-[(4-chlorophenyl)amino]pyridine-3-carboxylic acid

: 127555-68-4
1-(4-Chlorophenyl)-1,3-dihydro-3-(phenylthio)2H-pyrrolo[2,3-b]pyridin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / LiAlH₄ / tetrahydrofuran / 24 h / Heating

2: SOCl₂ / CH₂Cl₂ / 16 h / Ambient temperature

3: NaOH / ethanol; H₂O / 16 h / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00172a004