(R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester

Base Information

Chemical Name:(R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester
CAS No.:340963-64-6
Molecular Formula:C₃₄H₄₂N₂O₆Si
Molecular Weight:602.803
Hs Code.:

Synonyms:(R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester

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Chemical Property of (R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester

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Technology Process of (R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester

There total 11 articles about (R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-36-5
acetyl chloride

: 340963-77-1
acetic acid {allyl-[1-(3-amino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-methyl ester

: 340963-64-6
(R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jo015512q

Reference yield:

: 82807-38-3
1-(2-methoxyphenyl)ethane-1,2-diol

: 340963-64-6
(R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 94 percent / pyridine / 8 h / 20 °C

2: 83 percent / KNO₃; TFAA / CHCl₃ / 48 h / 0 °C

3: 93 percent / K₂CO₃ / methanol; H₂O / 0.5 h

4: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

5: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

6: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

7: 78 percent / 4 Angstroem MS; CsOH*H₂O / dimethylformamide

8: 86 percent / Et₃N / diethyl ether / 0 - 20 °C

9: 76 percent / ethyl viologen dibromide; K₂CO₃; Na₂S₂O₄ / CH₂Cl₂; H₂O / 24 h

10: 402.1 mg / Et₃N / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; cesium hydroxide; sodium dithionite; 4 Angstroem MS; potassium carbonate; hydrazine hydrate; potassium nitrate; triethylamine; triphenylphosphine; 1,1′-diethyl-[4,4′-bipyridine]-1,1′-diium dibromide; trifluoroacetic anhydride; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; 5: Mitsunobu reaction;
DOI:10.1021/jo015512q

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 340963-64-6
(R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 89 percent / PPh₃; DEAD / tetrahydrofuran / 1.5 h

3: 100 percent / NH₂NH₂*H₂O / ethanol / 3 h / Heating

4: 78 percent / 4 Angstroem MS; CsOH*H₂O / dimethylformamide

5: 86 percent / Et₃N / diethyl ether / 0 - 20 °C

6: 76 percent / ethyl viologen dibromide; K₂CO₃; Na₂S₂O₄ / CH₂Cl₂; H₂O / 24 h

7: 402.1 mg / Et₃N / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; cesium hydroxide; sodium dithionite; 4 Angstroem MS; potassium carbonate; hydrazine hydrate; triethylamine; triphenylphosphine; 1,1′-diethyl-[4,4′-bipyridine]-1,1′-diium dibromide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jo015512q