(R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate

Base Information

• Chemical Name: (R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate
• CAS No.: 1240521-73-6
• Molecular Formula: C₂₆H₂₂N₄O₇S
• Molecular Weight: 534.549
• Mol file: 1240521-73-6.mol

Synonyms:(R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate

Chemical Property of (R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate

There total 7 articles about (R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(R)-2-hydroxy-N-(6-methoxy-[3,4′-bipyridin]-5-yl)-3-phenylpropanamide (1240521-72-5) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → (R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate (1240521-73-6)

Guidance literature:

With triethylamine;

DOI:10.1016/j.bmcl.2012.08.015

Reference yield:

5-bromo-2-(methyloxy)-3-pyridinamine (884495-39-0) → (R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate (1240521-73-6)

Guidance literature:

Multi-step reaction with 4 steps

1: XPhos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / butan-1-ol / 3 h / 110 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: potassium carbonate

4: triethylamine

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; XPhos; In dichloromethane; butan-1-ol; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2012.08.015

Reference yield:

4-pyridylboronic acid (1692-15-5) → (R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate (1240521-73-6)

Guidance literature:

Multi-step reaction with 4 steps

1: XPhos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / butan-1-ol / 3 h / 110 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: potassium carbonate

4: triethylamine

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; XPhos; In dichloromethane; butan-1-ol; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2012.08.015

upstream raw materials:

(R)-2-hydroxy-N-(6-methoxy-[3,4′-bipyridin]-5-yl)-3-phenylpropanamide

4-Nitrobenzenesulfonyl chloride

(R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl acetate

4-pyridylboronic acid

Downstream raw materials:

(S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide

C₂₄H₂₂N₆O₂

C₂₄H₂₅N₅O₃

C₂₆H₂₅N₅O₂