(S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide

Base Information

• Chemical Name: (S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide
• CAS No.: 1240521-74-7
• Molecular Formula: C₂₈H₂₇N₅O₂
• Molecular Weight: 465.555
• Mol file: 1240521-74-7.mol

Synonyms:(S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide

Chemical Property of (S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide

There total 8 articles about (S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate (1240521-73-6) + 1-(pyridin-2-yl)cyclopropan-1-amine (503417-37-6) → (S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide (1240521-74-7)

Guidance literature:

In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1016/j.bmcl.2012.08.015

Reference yield:

5-bromo-2-(methyloxy)-3-pyridinamine (884495-39-0) → (S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide (1240521-74-7)

Guidance literature:

Multi-step reaction with 5 steps

1: XPhos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / butan-1-ol / 3 h / 110 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: potassium carbonate

4: triethylamine

5: N,N-dimethyl-formamide / 100 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; XPhos; In dichloromethane; N,N-dimethyl-formamide; butan-1-ol; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2012.08.015

Reference yield:

4-pyridylboronic acid (1692-15-5) → (S)-N-(2-methoxy-5-(pyridin-4-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide (1240521-74-7)

Guidance literature:

Multi-step reaction with 5 steps

1: XPhos; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / butan-1-ol / 3 h / 110 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane

3: potassium carbonate

4: triethylamine

5: N,N-dimethyl-formamide / 100 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; XPhos; In dichloromethane; N,N-dimethyl-formamide; butan-1-ol; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2012.08.015

upstream raw materials:

(R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl 4-nitrobenzenesulfonate

1-(pyridin-2-yl)cyclopropan-1-amine

(R)-1-(2-methoxy-5-(pyridine-4-yl)pyridine-3-ylamino)-1-oxo-3-phenylpropan-2-yl acetate

(R)-2-hydroxy-N-(6-methoxy-[3,4′-bipyridin]-5-yl)-3-phenylpropanamide

Downstream raw materials:

C₂₇H₂₅N₅O₂

C₃₃H₃₅N₅O₄

C₂₉H₂₇N₅O₄

C₃₁H₃₄N₆O₂