(6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine

Base Information

Chemical Name:(6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine
CAS No.:869794-17-2
Molecular Formula:C₁₇H₂₆N₂O
Molecular Weight:274.406
Hs Code.:

Synonyms:(6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine

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Chemical Property of (6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine

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Technology Process of (6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine

There total 9 articles about (6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869794-16-1
(6R,9aS)-2-benzyl-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine

: 869794-17-2
(6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine

Guidance literature:: (6R,9aS)-2-benzyl-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine; With ammonium formate; palladium(II) hydroxide/carbon; In methanol; for 2h; Heating / reflux;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 869794-14-9
(E)-1-((S)-4-Benzyl-piperazin-2-yl)-4-(4-methoxy-2,3-dimethylphenyl)-but-3-en-2-one

: 869794-17-2
(6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / methanol; water / 16.5 h / 20 - 60 °C

2.1: tetrahydrofuran; methanol / 20.5 h / 20 °C

3.1: zinc trifluoromethanesulfonate; sodium cyanoborohydride / tetrahydrofuran; methanol / 5.5 h / 65 °C

3.2: 0.5 h

4.1: ammonium formate / palladium(II) hydroxide/carbon / methanol / 2 h / Heating / reflux

With ammonium acetate; ammonium formate; zinc trifluoromethanesulfonate; sodium cyanoborohydride; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol; water;

Reference yield:

: 869794-15-0
(6R,9aS)-2-benzyl-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazin-8-one

: 869794-17-2
(6R,9aS)-6-(4-methoxy-2,3-dimethylphenyl)-octahydro-pyrido[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; methanol / 20.5 h / 20 °C

2.1: zinc trifluoromethanesulfonate; sodium cyanoborohydride / tetrahydrofuran; methanol / 5.5 h / 65 °C

2.2: 0.5 h

3.1: ammonium formate / palladium(II) hydroxide/carbon / methanol / 2 h / Heating / reflux

With ammonium formate; zinc trifluoromethanesulfonate; sodium cyanoborohydride; palladium(II) hydroxide/carbon; In tetrahydrofuran; methanol;