dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate

Base Information

Chemical Name:dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate
CAS No.:934365-26-1
Molecular Formula:C₂₅H₂₉N₂O₈P
Molecular Weight:516.488
Hs Code.:

Synonyms:dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate

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Chemical Property of dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate

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Technology Process of dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate

There total 6 articles about dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 950692-66-7
C₂₃H₂₂N₂O₅

: 868-85-9
Dimethyl phosphite

: 934365-26-1
dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate

Guidance literature:: With triethylamine; In methanol;
DOI:10.1016/j.bmcl.2006.12.009

Reference yield:

: 934365-24-9
C₂₃H₂₂N₂O₅

: 934365-26-1
dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: CH(OEt)3 / PTS

2: diisobutylaluminum hydride / toluene / -78 °C

3: triethylamine / methanol

With diisobutylaluminium hydride; triethylamine; orthoformic acid triethyl ester; pyridinium p-toluenesulfonate; In methanol; toluene; 3: Pudovik reaction;
DOI:10.1016/j.bmcl.2006.12.009

Reference yield:

: 57667-73-9
N,N'-dibenzyluracil-5-carbaldehyde

: 934365-26-1
dimethyl 3-(1,3-dibenzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-3,3-ethylenedioxy-1-hydroxypropylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride / CH₂Cl₂

2: CH(OEt)3 / PTS

3: diisobutylaluminum hydride / toluene / -78 °C

4: triethylamine / methanol

With diisobutylaluminium hydride; triethylamine; orthoformic acid triethyl ester; tin(ll) chloride; pyridinium p-toluenesulfonate; In methanol; dichloromethane; toluene; 4: Pudovik reaction;
DOI:10.1016/j.bmcl.2006.12.009