2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine

Base Information

• Chemical Name: 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine
• CAS No.: 131920-32-6
• Molecular Formula: C₄₀H₃₈N₆O₉
• Molecular Weight: 746.777

Synonyms:2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine

Chemical Property of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine

Chemical Property:

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Technology Process of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine

There total 1 articles about 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-deoxy-N6-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine (88091-69-4) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine (131920-32-6)

Guidance literature:

In pyridine; at 20 ℃;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2172::AID-HLCA2172>3.0.CO;2-R

Reference yield: 92.0%

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) + 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine (131920-32-6) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite) (129926-66-5)

Guidance literature:

With 1H-tetrazole; In dichloromethane; at 20 ℃; for 2.5h;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2172::AID-HLCA2172>3.0.CO;2-R

Reference yield: 87.0%

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine (131920-32-6) + 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite (153120-90-2) → 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxy-N6-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine phosphoramidite

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2172::AID-HLCA2172>3.0.CO;2-R

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-deoxy-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine

Downstream raw materials:

4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁶-[2-(4-nitrophenyl)ethoxycarbonyl]adenosine 3'-(2-cyanoethyl diisopropylphosphoramidite)

5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-2'-deoxyadenosine

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