N-(methylsulfonyl)-N-[2-(methylthio)-4-oxo-6-phenylthieno[2,3-d]pyrimidin-4(3H)-yl]methanesulfonamide

Base Information

Chemical Name:N-(methylsulfonyl)-N-[2-(methylthio)-4-oxo-6-phenylthieno[2,3-d]pyrimidin-4(3H)-yl]methanesulfonamide
CAS No.:639825-32-4
Molecular Formula:C₁₅H₁₅N₃O₅S₄
Molecular Weight:445.565
Hs Code.:

Synonyms:N-(methylsulfonyl)-N-[2-(methylthio)-4-oxo-6-phenylthieno[2,3-d]pyrimidin-4(3H)-yl]methanesulfonamide

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Chemical Property of N-(methylsulfonyl)-N-[2-(methylthio)-4-oxo-6-phenylthieno[2,3-d]pyrimidin-4(3H)-yl]methanesulfonamide

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Technology Process of N-(methylsulfonyl)-N-[2-(methylthio)-4-oxo-6-phenylthieno[2,3-d]pyrimidin-4(3H)-yl]methanesulfonamide

There total 5 articles about N-(methylsulfonyl)-N-[2-(methylthio)-4-oxo-6-phenylthieno[2,3-d]pyrimidin-4(3H)-yl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 124-63-0
methanesulfonyl chloride

: 335274-90-3
3-amino-2-(methylthio)-6-phenyl-thieno[2,3-d]pyrimidin-4(3H)-one

: 639825-32-4
N-(methylsulfonyl)-N-[2-(methylthio)-4-oxo-6-phenylthieno[2,3-d]pyrimidin-4(3H)-yl]methanesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1002/jhet.5570400519

Reference yield:

: 4815-34-3
ethyl 2-amino-5-phenylthiophene-3-carboxylate

: 639825-32-4
N-(methylsulfonyl)-N-[2-(methylthio)-4-oxo-6-phenylthieno[2,3-d]pyrimidin-4(3H)-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 50 percent / acetone / 0.33 h / 20 °C

2: 55 percent / H₂NNH₂*H₂O / CHCl₃ / 2 h / 20 °C

3: 80 percent / NaOH; EtOH / 1 h / Heating

4: 60 percent / H₂O / 1.5 h / 20 °C

5: 68 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; ethanol; hydrazine hydrate; triethylamine; In dichloromethane; chloroform; water; acetone;
DOI:10.1002/jhet.5570400519

Reference yield:

: 85716-86-5
2-isothiocyanato-5-phenyl-3-thiophenecarboxylic acid ethyl ester

: 639825-32-4
N-(methylsulfonyl)-N-[2-(methylthio)-4-oxo-6-phenylthieno[2,3-d]pyrimidin-4(3H)-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 55 percent / H₂NNH₂*H₂O / CHCl₃ / 2 h / 20 °C

2: 80 percent / NaOH; EtOH / 1 h / Heating

3: 60 percent / H₂O / 1.5 h / 20 °C

4: 68 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With sodium hydroxide; ethanol; hydrazine hydrate; triethylamine; In dichloromethane; chloroform; water;
DOI:10.1002/jhet.5570400519