3-amino-2-(methylsulfanyl)-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:3-amino-2-(methylsulfanyl)-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one
CAS No.:335274-90-3
Molecular Formula:C₁₃H₁₁N₃OS₂
Molecular Weight:289.382
Hs Code.:
Mol file:335274-90-3.mol

Synonyms:3-amino-2-(methylthio)-6-phenyl-thieno[2,3-d]pyrimidin-4(3H)-one

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Chemical Property of 3-amino-2-(methylsulfanyl)-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one

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Technology Process of 3-amino-2-(methylsulfanyl)-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one

There total 5 articles about 3-amino-2-(methylsulfanyl)-6-phenylthieno[2,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 2,3-dihydro-3-amino-6-phenyl-2-thioxothieno<2,3-d>pyrimidin-4(1H)-one potassium salt

: 74-88-4
methyl iodide

: 335274-90-3
3-amino-2-(methylthio)-6-phenyl-thieno[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: In water; at 20 ℃;
DOI:10.1016/S0223-5234(00)01187-9 DOI:10.1016/S0223-5234(01)01216-8

Reference yield: 60.0%

: 3-amino-2,3-dihydro-6-phenyl-2-thioxothieno[2,3-d]pyrimidin-4(1H)-one sodium salt

: 74-88-4
methyl iodide

: 335274-90-3
3-amino-2-(methylthio)-6-phenyl-thieno[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: In water; at 20 ℃; for 1.5h;
DOI:10.1002/jhet.5570400519

Reference yield:

: 4815-34-3
ethyl 2-amino-5-phenylthiophene-3-carboxylate

: 335274-90-3
3-amino-2-(methylthio)-6-phenyl-thieno[2,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / acetone / 0.33 h / 20 °C

2: 55 percent / H₂NNH₂*H₂O / CHCl₃ / 2 h / 20 °C

3: 80 percent / NaOH; EtOH / 1 h / Heating

4: 60 percent / H₂O / 1.5 h / 20 °C

With sodium hydroxide; ethanol; hydrazine hydrate; In chloroform; water; acetone;
DOI:10.1002/jhet.5570400519