4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-4-phenyl-butyric acid

Base Information

• Chemical Name: 4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-4-phenyl-butyric acid
• CAS No.: 103186-04-5
• Molecular Formula: C₁₉H₂₀O₄
• Molecular Weight: 312.365
• Mol file: 103186-04-5.mol

Synonyms:4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-4-phenyl-butyric acid

Chemical Property of 4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-4-phenyl-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-4-phenyl-butyric acid

There total 7 articles about 4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-4-phenyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-phenyl-2-methylenebutyrolactone (26613-71-8) + 2,3,5-Trimethyl-1,4-benzoquinone (935-92-2) → 4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-4-phenyl-butyric acid (103186-04-5)

Guidance literature:

4-phenyl-2-methylenebutyrolactone; 2,3,5-Trimethyl-1,4-benzoquinone; With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; at 20 ℃; for 0.5h;

With hafnium tetrakis(trifluoromethanesulfonate); at 70 ℃; for 6h;

DOI:10.1021/acs.orglett.9b01672

Reference yield: 38.0%

4,5-dihydro-5-phenyl-2(3H)-furanone (1008-76-0) + 2N-hydrochloric acid + Trimethylhydroquinone (700-13-0) + 1,2-dichloro-ethane (107-06-2,52399-93-6) → 4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-4-phenyl-butyric acid (103186-04-5)

Guidance literature:

With iron(III) chloride; aluminium trichloride; In tetrahydrofuran;

Reference yield:

4-(2,5-dihydroxy-3,4,6-trimethylphenyl)-4-phenylbutanoic acid → 4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)-4-phenyl-butyric acid (103186-04-5)

Guidance literature:

With iron(III) chloride; In tetrahydrofuran; Yield given; Ambient temperature;

DOI:10.1021/jm00129a030

upstream raw materials:

4,5-dihydro-5-phenyl-2(3H)-furanone

Trimethylhydroquinone

benzene

1,2-dichloro-ethane

Downstream raw materials:

ethyl 4-phenyl-4-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)butanoate