N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-6-fluoronicotinamide

Base Information

Chemical Name:N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-6-fluoronicotinamide
CAS No.:1447018-00-9
Molecular Formula:C₂₈H₂₂BrFN₄O₃S
Molecular Weight:593.476
Hs Code.:

Synonyms:N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-6-fluoronicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-6-fluoronicotinamide

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Technology Process of N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-6-fluoronicotinamide

There total 4 articles about N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-6-fluoronicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1447017-93-7
2-amino-N-(3-(benzylthio)-2-(methylcarbamoyl)phenyl)-6-bromobenzamide

: 65352-94-5
6-fluoronicotinoyl chloride

: 1447018-00-9
N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-6-fluoronicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling with ice;
DOI:10.1016/j.cclet.2013.04.047

Reference yield:

: 403-45-2
6-fluoronicotinic acid

: 1447018-00-9
N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-6-fluoronicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.cclet.2013.04.047

Reference yield:

: 1447017-92-6
2-amino-6-bromo-N-(3-bromo-2-(methylcarbamoyl)phenyl)benzamide

: 1447018-00-9
N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-6-fluoronicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.cclet.2013.04.047