AC-LEU-PRO-PHE-PHE-ASP-NH2

Base Information

• Chemical Name: AC-LEU-PRO-PHE-PHE-ASP-NH2
• CAS No.: 339990-02-2
• Molecular Formula: C₃₅H₄₆N₆O₈
• Molecular Weight: 678.786
• Mol file: 339990-02-2.mol

Synonyms:10:PN: WO03050139 SEQID: 15 claimed protein; 3: PN: WO0134631 PAGE: 35 claimedprotein; 7: PN: WO2004096845 SEQID: 5 claimed sequence; AS 602704

Chemical Property of AC-LEU-PRO-PHE-PHE-ASP-NH2

Chemical Property:

• Boiling Point: 1107.4±65.0 °C(Predicted)
• PKA: 4.07±0.10(Predicted)
• PSA: 217.10000
• Density: 1.268±0.06 g/cm3(Predicted)
• LogP: 2.62980

Purity/Quality:

99%+, ^*data from raw suppliers

Acetyl-(Pro18,Asp21)-Amyloid b-Protein (17-21) amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AC-LEU-PRO-PHE-PHE-ASP-NH2

There total 1 articles about AC-LEU-PRO-PHE-PHE-ASP-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Leu-OH (35661-60-0) + Fmoc-Pro-OH (71989-31-6) + N-Fmoc L-Phe (35661-40-6) + Fmoc-(tBu)Asp-OH (71989-14-5) + acetic anhydride (108-24-7) → Ac-Leu-Pro-Phe-Phe-Asp(OH)-NH2 (339990-02-2)

Guidance literature:

Fmoc-(tBu)Asp-OH; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; MBHA-Rinkamide resin

With piperidine; In N,N-dimethyl-formamide; MBHA-Rinkamide resin

Fmoc-Leu-OH; Fmoc-Pro-OH; N-Fmoc L-Phe; acetic anhydride; Further stages;

DOI:10.1111/cbdd.12912

upstream raw materials:

Fmoc-Leu-OH

Fmoc-Pro-OH

N-Fmoc L-Phe

Fmoc-(tBu)Asp-OH

Refernces