2-ethoxy-2-oxo-1-phenylethyl thiophene-2-carboxylate

Base Information

• Chemical Name: 2-ethoxy-2-oxo-1-phenylethyl thiophene-2-carboxylate
• CAS No.: 1268358-91-3
• Molecular Formula: C₁₅H₁₄O₄S
• Molecular Weight: 290.34
• Mol file: 1268358-91-3.mol

Synonyms:2-ethoxy-2-oxo-1-phenylethyl thiophene-2-carboxylate

Chemical Property of 2-ethoxy-2-oxo-1-phenylethyl thiophene-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-ethoxy-2-oxo-1-phenylethyl thiophene-2-carboxylate

There total 3 articles about 2-ethoxy-2-oxo-1-phenylethyl thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

thiophene-2-carbaldehyde (98-03-3) + phenylglyoxylic acid ethyl ester (1603-79-8) → 2-ethoxy-2-oxo-1-phenylethyl thiophene-2-carboxylate (1268358-91-3)

Guidance literature:

With 1,3-bis(mesityl)imidazolium chloride; triethylamine; In tetrahydrofuran; at 25 ℃; for 6h; regioselective reaction; Inert atmosphere; Combinatorial reaction / High throughput screening (HTS);

DOI:10.1016/j.tetlet.2010.12.022

Reference yield:

C15H14O3S → 2-ethoxy-2-oxo-1-phenylethyl thiophene-2-carboxylate (1268358-91-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.9b02323

Reference yield:

ethoxyethynylbenzene (32569-84-9) → 2-ethoxy-2-oxo-1-phenylethyl thiophene-2-carboxylate (1268358-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: silver(l) oxide / 1,4-dioxane / 5 h / 100 °C / Schlenk technique; Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / 1,4-dioxane / 12 h / 20 °C / Schlenk technique; Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; In 1,4-dioxane;

DOI:10.1021/acs.orglett.9b02323

upstream raw materials:

thiophene-2-carbaldehyde

phenylglyoxylic acid ethyl ester

ethoxyethynylbenzene