Technology Process of 6-(2,4-dimethoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine
There total 1 articles about 6-(2,4-dimethoxybenzyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 18h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2010.08.091
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid; triethylsilane / 4 h / 60 - 65 °C
1.2: 20 °C
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 25 - 35 °C
3.1: hydrogen; 5%-palladium/activated carbon / toluene / 24 h / 80 °C / 6000.6 Torr
3.2: Reflux
With
triethylsilane; 5%-palladium/activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; toluene;
DOI:10.14233/ajchem.2013.15245
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trifluoroacetic acid; triethylsilane / 4 h / 60 - 65 °C
1.2: 20 °C
2.1: sodium carbonate; phenylboronic acid / water; o-xylene / 24 h / Reflux
3.1: hydrogen; 5%-palladium/activated carbon / toluene / 24 h / 80 °C / 6000.6 Torr
4.1: hydrogenchloride / isopropyl alcohol / 5 h / pH < 2
4.2: pH 10
5.1: potassium hydroxide / methanol / 72 h / Reflux
With
hydrogenchloride; triethylsilane; 5%-palladium/activated carbon; hydrogen; sodium carbonate; trifluoroacetic acid; potassium hydroxide; phenylboronic acid;
In
methanol; o-xylene; water; isopropyl alcohol; toluene;
DOI:10.14233/ajchem.2013.15245
