6-(3-chloro-4-fluorophenyl)picolinaldehyde

Base Information

• Chemical Name: 6-(3-chloro-4-fluorophenyl)picolinaldehyde
• CAS No.: 1401165-63-6
• Molecular Formula: C₁₂H₇ClFNO
• Molecular Weight: 235.645
• Mol file: 1401165-63-6.mol

Synonyms:6-(3-chloro-4-fluorophenyl)picolinaldehyde

Chemical Property of 6-(3-chloro-4-fluorophenyl)picolinaldehyde

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

6-(3-Chloro-4-fluorophenyl)picolinaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(3-chloro-4-fluorophenyl)picolinaldehyde

There total 1 articles about 6-(3-chloro-4-fluorophenyl)picolinaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-bromo-2-pyridinecarbaldehyde (34160-40-2) + 3-chloro-4-fluorophenylboronic acid (144432-85-9) → 6-(3-chloro-4-fluorophenyl)picolinaldehyde (1401165-63-6)

Guidance literature:

6-bromo-2-pyridinecarbaldehyde; 3-chloro-4-fluorophenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; toluene; at 110 ℃; for 7h; Inert atmosphere;

With sodium carbonate; In methanol; water; toluene; for 0.0833333h;

DOI:10.1016/j.ejmech.2016.12.024

Reference yield: 59.0%

6-(3-chloro-4-fluorophenyl)picolinaldehyde (1401165-63-6) + (1-aminocyclopentyl)methanol (10316-79-7) → [1-({[6-(3-chloro-4-fluorophenyl)pyridin-2-yl]methyl}amino)cyclopentyl]methanol (1401165-62-5)

Guidance literature:

With acetic acid; In methanol; dichloromethane; at 20 ℃; for 2h;

Reference yield: 40.0%

6-(3-chloro-4-fluorophenyl)picolinaldehyde (1401165-63-6) + 1-amino-3-(dimethylamino)propane (109-55-7) → N1-((6-(3-chloro-4-fluorophenyl)pyridin-2-yl)methyl)-N3,N3-dimethylpropane-1,3-diamine

Guidance literature:

6-(3-chloro-4-fluorophenyl)picolinaldehyde; 1-amino-3-(dimethylamino)propane; In dichloromethane; for 24h;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 24h;

DOI:10.1016/j.ejmech.2016.12.024

upstream raw materials:

6-bromo-2-pyridinecarbaldehyde

3-chloro-4-fluorophenylboronic acid

Downstream raw materials:

[1-({[6-(3-chloro-4-fluorophenyl)pyridin-2-yl]methyl}amino)cyclopentyl]methanol

Refernces

• 1、 -. "TRPV3 Modulators". Page/Page column 71. . Retrieved 2012/10/08.