4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine

Base Information

• Chemical Name: 4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine
• CAS No.: 1242020-17-2
• Molecular Formula: C₁₂H₁₃F₂N₃O
• Molecular Weight: 253.252
• Mol file: 1242020-17-2.mol

Synonyms:4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine

Chemical Property of 4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine

There total 3 articles about 4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,6-difluoro-4-methoxyphenyl)-3-oxobutanenitrile (1242020-16-1) + methylhydrazine (60-34-4) → 4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine (1242020-17-2)

Guidance literature:

With acetic acid; In ethanol; for 16h; Reflux; Inert atmosphere;

Reference yield:

methyldiazene (22038-72-8,26981-93-1,51943-20-5) + 2-(2,6-difluoro-4-methoxyphenyl)acetonitrile (886499-03-2) + ethyl acetate (141-78-6) → 4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine (1242020-17-2)

Guidance literature:

2-(2,6-difluoro-4-methoxyphenyl)acetonitrile; With sodium ethanolate; In ethanol; toluene; for 0.25h; Reflux;

ethyl acetate; In ethanol; toluene; for 2h; Reflux;

methyldiazene; With acetic acid; In ethanol; for 2h; Reflux;

Reference yield:

2-(2,6-difluoro-4-methoxyphenyl)acetonitrile (886499-03-2) → 4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl amine (1242020-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethanolate / ethyl acetate; ethanol; xylene / 4 h / 50 °C

2: acetic acid / ethanol / 16 h / Reflux

With sodium ethanolate; acetic acid; In ethanol; ethyl acetate; xylene;

upstream raw materials:

2-(2,6-difluoro-4-methoxyphenyl)-3-oxobutanenitrile

methylhydrazine

2-(2,6-difluoro-4-methoxyphenyl)acetonitrile

methyldiazene

Downstream raw materials:

3-bromo-4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazole

4-(2,6-difluoro-4-methoxyphenyl)-1,3-dimethyl-N-(2,4,6-trifluorophenyl)-1H-pyrazol-5 amine

[4-(2,6-difluoro-4-methoxyphenyl)-2-methyl-5-methyl-2H-pyrazol-3-yl](2,4-difluorophenyl)methanol