(S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid

Base Information

• Chemical Name: (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid
• CAS No.: 788799-69-9
• Molecular Formula: C15H26 N2 O6
• Molecular Weight: 330.381
• Hs Code.: 2933599090
• Mol file: 788799-69-9.mol

Synonyms:1,2,4-Piperazinetricarboxylicacid, 1,4-bis(1,1-dimethylethyl) ester, (S)-

Chemical Property of (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.503
• Boiling Point: 443.888°C at 760 mmHg
• Flash Point: 222.256°C
• PSA: 96.38000
• Density: 1.201g/cm³
• LogP: 1.80320
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(S)-1,4-Bis(tert-butoxycarbonyl)piperazine-2-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid

There total 3 articles about (S)-1,4-N-Diboc-2-piperazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + S-(-)-piperazine-2-carboxylic acid dihydrochloride → (2S)-1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid (788799-69-9)

Guidance literature:

With sodium hydroxide; In 1,2-dioxacyclohexane; water; at 0 - 20 ℃; for 16h;

Reference yield: 100.0%

(2S)-piperazinecarboxylic acid bis-(+)camphor sulfonic acid + di-tert-butyl dicarbonate (24424-99-5) → (2S)-1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid (788799-69-9)

Guidance literature:

With methanol; water;

Reference yield: 99.0%

di-tert-butyl dicarbonate (24424-99-5) + (2S)-piperazine-2-carboxylic acid (147650-70-2) → (2S)-1,4-bis(tert-butoxycarbonyl)piperazine-2-carboxylic acid (788799-69-9)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; at 23 ℃; for 20h;

DOI:10.1021/jo701465h

upstream raw materials:

di-tert-butyl dicarbonate

(2S)-piperazine-2-carboxylic acid

Downstream raw materials:

1,4-di-tert-butyl 2-methyl (2S)-piperazine-1,2,4-tricarboxylate

C₁₅H₂₉N₃O₄

(-)-N₁,N₄-di-(tert-butyloxycarbonyl)-N-[3-[(1H-imidazol-1-yl)-methyl]phenyl]-(2S)-piperazinecarboxamide

(3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester