1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester
• CAS No.: 1280201-06-0
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348

Synonyms:1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Chemical Property of 1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

There total 4 articles about 1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280200-63-6) + ethyl iodide (75-03-6) → 1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280201-06-0)

Guidance literature:

1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -50 - 0 ℃;

ethyl iodide; In tetrahydrofuran; at -50 - 20 ℃; for 2h; Product distribution / selectivity;

Reference yield:

2-methylenesuccinic acid (97-65-4,25119-64-6) → 1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280201-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.75 h / 130 °C

2.1: acetyl chloride / 1 h / 64 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -50 - 0 °C

3.2: 2 h / -50 - 20 °C

With acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran;

Reference yield:

2,6-dimethylaniline (87-62-7) → 1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester (1280201-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.75 h / 130 °C

2.1: acetyl chloride / 1 h / 64 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -50 - 0 °C

3.2: 2 h / -50 - 20 °C

With acetyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran;

upstream raw materials:

2-methylenesuccinic acid

2,6-dimethylaniline

1-(2,6-dimethylphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

ethyl iodide

Downstream raw materials:

N-(3-chloro-5-(trifluoromethyl)phenyl)-3-ethyl-1-(2,6-dimethylphenyl)-5-oxopyrrolidine-3-carboxamide

C₁₇H₂₃NO₃

1-(2,6-dimethylphenyl)-3-ethyl-4-hydroxy-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

(S)-N-(3,5-bis(trifluoromethyl)phenyl)-1-(2,6 dimethylphenyl)-3-ethyl-5-oxopyrrolidine-3-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1280201-06-0 1-(2,6-dimethylphenyl)-3-ethyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send