2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Base Information

Chemical Name:2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid
CAS No.:1369962-49-1
Molecular Formula:C₂₆H₂₅N₅O₆S
Molecular Weight:535.58
Hs Code.:

Synonyms:2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

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Chemical Property of 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

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Technology Process of 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

There total 9 articles about 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369963-17-6
prop-2-en-1-yl 2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoate

: 1369962-49-1
2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Guidance literature:: With morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetonitrile; for 0.5h; Cooling with ice;

Reference yield:

: 18144-47-3
tert-butyl 4-aminobenzoate

: 1369962-49-1
2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine / dichloromethane / 1 h / Cooling with ice

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

3: sodium hydroxide; water / ethanol; methanol / 0.5 h / Cooling with ice

4: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere; Cooling with ice

8: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.5 h / Cooling with ice

With morpholine; pyridine; dmap; di-isopropyl azodicarboxylate; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1369962-49-1
2-[{4-[(4-methylphenyl)carbamoyl]phenyl}(methylsulfonyl)amino]-4-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)butanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: dmap; di-tert-butyl dicarbonate / tetrahydrofuran / 10 h / 20 °C

1.2: 6 h / 35 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 h / 3102.97 Torr

3.1: pyridine / dichloromethane / 1 h / Cooling with ice

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

5.1: sodium hydroxide; water / ethanol; methanol / 0.5 h / Cooling with ice

6.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

9.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere; Cooling with ice

10.1: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.5 h / Cooling with ice

With morpholine; pyridine; dmap; di-tert-butyl dicarbonate; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;